Colibactin genes are highly prevalent in the developing infant gut microbiome.

Early-life exposure to colibactin-producing + gut bacteria is hypothesized to imprint mutations on the colorectal epithelium, increasing the risk of colorectal cancer later in life. We demonstrate an extremely high prevalence of bacteria (>50% of infants) during the first two years of life, suggesting carriage is likely normal during early-life microbiome development. Further research is needed into the conditions in which carriage can lead to mutagenesis.

Perioperative Anaphylaxis: A Systematic Approach to Evaluate High-Risk Drug Allergy.

Determining the etiology of perioperative anaphylaxis is a challenging task, as multiple medications are often administered simultaneously during anesthesia. This is compounded by the paucity of validated skin testing. While drug challenges are the definitive means of assessing for IgE-mediated drug allergy, they must be weighed with the risk of severe reaction.