Total liquid ventilation in an ovine model of extreme prematurity: a randomized study.

Background: This study aimed at comparing cardiorespiratory stability during total liquid ventilation (TLV)-prior to lung aeration-with conventional mechanical ventilation (CMV) in extremely preterm lambs during the first 6 h of life.

Methods: 23 lambs (11 females) were born by c-section at 118-120 days of gestational age (term = 147 days) to receive 6 h of TLV or CMV from birth. Lung samples were collected for RNA and histology analyses.

Hemodynamic impacts of apelin-13 in a neonatal lamb model of septic peritonitis.

Background: Apelins are potential candidate therapeutic molecules for hemodynamic support. The objective of this study was to assess the hemodynamic impacts of apelin-13 in a neonatal lamb model of septic shock.

Methods: Lambs were randomized to receive apelin-13 or normal saline.