Publications by authors named "Ellen D Arnstad"
Objective: We have previously shown that HLA-B27 was negatively associated with remission status eight years after the onset of juvenile idiopathic arthritis (JIA). We now aimed to study the associations of HLA-B27 with clinical features and disease outcomes 18 years after the onset of JIA.
Methods: We studied 434 patients from the population-based Nordic JIA cohort.
Article Synopsis
- The study aimed to evaluate patients with juvenile idiopathic arthritis (JIA) to see how many fit the criteria for psoriatic arthritis (PsA) 18 years after the disease began.
- Of the 510 initially enrolled patients, only 434 participated in follow-up, with 9.4% meeting the CASPAR criteria for PsA, indicating CASPAR may be more effective in identifying these patients than the ILAR criteria.
- Key predictors for developing PsA included specific joint involvement at disease onset and the presence of psoriasis, nail abnormalities, or dactylitis, with dactylitis being the strongest predictor.
Objectives: To assess the ability of baseline serum biomarkers to predict disease activity and remission status in juvenile idiopathic arthritis (JIA) at 18-year follow-up (FU) in a population-based setting.
Methods: Clinical data and serum levels of inflammatory biomarkers were assessed in the longitudinal population-based Nordic JIA cohort study at baseline and at 18-year FU. A panel of 16 inflammatory biomarkers was determined by multiplexed bead array assay.
Background: There is a growing interest concerning the relationship between obesity and several medical conditions and inflammation. Nevertheless, there is a lack of studies regarding body mass index (BMI) among patients with juvenile idiopathic arthritis (JIA). Our aim was to investigate the impact of BMI on health-related quality of life (HRQoL) measured with a 36-Item Short Form Survey (SF-36), disease activity, and disability in young adults with JIA.
View Article and Find Full Text PDFTransitioning patients with juvenile idiopathic arthritis to adult care: the Nordic experience.
Pediatr Rheumatol Online J
October 2022
Article Synopsis
- - The study examines the transition process from pediatric to adult care for patients with juvenile idiopathic arthritis (JIA), focusing on transferral rates and disease activity in Nordic countries.
- - Out of 408 participants, 40% were directly transferred to adult clinics, with an overall transition rate of 52%; however, variations were noted across different centers.
- - Findings indicate the importance of improving transition practices, as 39% of patients who never transferred still experienced disease activity, suggesting a lack of adequate health care follow-up.
Changing Patterns in Treatment, Remission Status, and Categories in a Long-Term Nordic Cohort Study of Juvenile Idiopathic Arthritis.
Arthritis Care Res (Hoboken)
May 2022
Article Synopsis
- The study aimed to assess the long-term sustainability of remission without medication in juvenile idiopathic arthritis (JIA) patients and track changes in their disease categories over 18 years.
- Conducted on a cohort of 373 patients from the Nordic region, data were collected at three intervals: baseline, 8 years, and 18 years after disease onset, focusing on treatment, disease activity, and ILAR classification.
- Findings revealed that while more patients were off medication at the 18-year mark (70% vs. 59.7% after 8 years), the rate of remission remained stable (52% off vs. 51% on medication), and significant changes in ILAR categories occurred, particularly with an increase in
Fatigue in young adults with juvenile idiopathic arthritis 18 years after disease onset: data from the prospective Nordic JIA cohort.
Pediatr Rheumatol Online J
March 2021
Background: To study fatigue in young adults with juvenile idiopathic arthritis (JIA) 18 years after disease onset, and to compare with controls.
Methods: Consecutive children with onset of JIA between 1997 and 2000, from geographically defined areas of Norway, Sweden, Denmark and Finland were followed for 18 years in a close to population-based prospective cohort study. Clinical features, demographic and patient-reported data were collected.
Article Synopsis
- The study examined pain perception and sensitivity in young adults with a long history of juvenile idiopathic arthritis (JIA) compared to matched controls.
- It involved quantitative sensory testing to measure various pain thresholds and revealed that JIA participants had significantly lower pressure pain thresholds than controls.
- The findings suggest that younger adults with JIA experience altered pain sensitivity, but self-reported pain levels did not correlate with the assessed pain thresholds.
Purpose: To assess the long-term outcome of uveitis in juvenile idiopathic arthritis (JIA).
Design: Population-based, multicenter, prospective JIA cohort, with a cross-sectional assessment of JIA-associated uveitis (JIA-U) 18 years after the onset of JIA.
Participants: A total of 434 patients with JIA, of whom 96 had uveitis, from defined geographic areas of Denmark, Finland, Norway, and Sweden.
Background: Models to predict disease course and long-term outcome based on clinical characteristics at disease onset may guide early treatment strategies in juvenile idiopathic arthritis (JIA). Before a prediction model can be recommended for use in clinical practice, it needs to be validated in a different cohort than the one used for building the model. The aim of the current study was to validate the predictive performance of the Canadian prediction model developed by Guzman et al.
View Article and Find Full Text PDFObjective: To determine the prevalence of orofacial symptoms, dysfunctions, and deformities of the temporomandibular joint (TMJ) in juvenile idiopathic arthritis (JIA) 17 years after disease onset.
Methods: Drawn from a prospective, population-based Nordic JIA cohort with disease onset from 1997 to 2000, 420 consecutive cases were eligible for orofacial evaluation of TMJ involvement. The followup visit included demographic data, a standardized clinical orofacial examination, and full-face cone-beam computed tomography (CBCT).
Complement lectin pathway protein levels reflect disease activity in juvenile idiopathic arthritis: a longitudinal study of the Nordic JIA cohort.
Pediatr Rheumatol Online J
September 2019
Background: To determine the serum levels of the lectin pathway proteins early in the disease course and 17 years after disease onset and to correlate the protein levels to markers of disease activity in participants from a population-based Nordic juvenile idiopathic arthritis (JIA) cohort. Additionally, to assess the predictive value of lectin pathway proteins with respect to remission status.
Methods: A population-based cohort study of consecutive cases of JIA with a disease onset from 1997 to 2000 from defined geographical areas of Finland, Sweden, Norway and Denmark with 17 years of follow-up was performed.
Participation in school and physical education in juvenile idiopathic arthritis in a Nordic long-term cohort study.
Pediatr Rheumatol Online J
July 2019
Background: The aim of the study was to describe school attendance and participation in physical education in school among children with juvenile idiopathic arthritis (JIA).
Methods: Consecutive cases of JIA from defined geographical areas of Finland, Sweden and Norway with disease onset in 1997 to 2000 were followed for 8 years in a multi-center cohort study, aimed to be as close to population-based as possible. Clinical characteristics and information on school attendance and participation in physical education (PE) were registered.
Objective: The present study was undertaken to assess the long-term course, remission rate, and disease burden in juvenile idiopathic arthritis (JIA) 18 years after disease onset in a population-based setting from the early biologic era.
Methods: A total of 510 consecutive cases of JIA with disease onset between 1997 and 2000 from defined geographic regions in Denmark, Norway, Sweden, and Finland were prospectively included in this 18-year cohort study. At the follow-up visit, patient-reported demographic and clinical data were collected.
Objective: To study self-reported pain early in the disease course of juvenile idiopathic arthritis (JIA) as a predictor of long-term disease outcomes.
Methods: Consecutive cases of JIA with disease onset from 1997 to 2000 from defined geographical areas of Norway, Sweden, Finland, and Denmark were prospectively enrolled in this population-based cohort study. Self-reported, disease-related pain was measured on a 10-cm visual analog scale (VAS pain).
Background: The aim was to develop prediction rules that may guide early treatment decisions based on baseline clinical predictors of long-term unfavorable outcome in juvenile idiopathic arthritis (JIA).
Methods: In the Nordic JIA cohort, we assessed baseline disease characteristics as predictors of the following outcomes 8 years after disease onset. Non-achievement of remission off medication according to the preliminary Wallace criteria, functional disability assessed by Childhood Health Assessment Questionnaire (CHAQ) and Physical Summary Score (PhS) of the Child Health Questionnaire, and articular damage assessed by the Juvenile Arthritis Damage Index-Articular (JADI-A).