Publications by authors named "Elizabeth D Barker"
Drug penetration in pediatric brain tumors: Challenges and opportunities.
Pediatr Blood Cancer
June 2021
Article Synopsis
- Recent advancements in clinical trials and better understanding of biological differences have significantly improved survival rates for children with brain tumors over the past 50 years.
- Major challenges still exist in reducing long-term side effects and improving survival for high-risk tumors, as chemotherapy faces limitations in effectively reaching the tumor site.
- Barriers like the blood-brain barrier and characteristics of the tumor's environment hinder drug effectiveness, prompting the need for innovative drug delivery systems to enhance penetration and minimize harmful side effects.