Characterization, Epidemiology, and Outcomes of Periocular Dog Bites in Children.

Purpose: To characterize the presentation, management, epidemiology, and long-term outcomes of periocular dog bites in 150 pediatric patients at a tertiary referral center, Texas Children's Hospital in Houston, Texas.

Methods: We performed a retrospective chart review from 2011 to 2024 of patients with a diagnosis of "dog bite" or one of 120 eye-related International Classification of Disease (ICD)-10 codes, and an inpatient ophthalmology consult. We collected data on clinical presentation, work-up, management, and outcomes.

Incidence, Tumor Characteristics, and Prognostic Factors of Dermal and Subcutaneous Leiomyosarcoma of the Skin: A Retrospective Analysis of the Surveillance, Epidemiology, and End Results Database.

Background: Population-based investigations of leiomyosarcoma (LMS) of the skin are limited; many studies of LMS have not stratified results by dermal versus subcutaneous origin of the tumor.

Objective: To characterize the incidence, tumor characteristics, and prognostic factors of skin primary LMS.

Methods: Retrospective population-based analysis of the 17 registries of the Surveillance, Epidemiology, and End Results Program (2000-2021).

Tools and methods for cataract recognition in low-resource settings: A narrative review.

Cataracts are a leading cause of global blindness, with many low-resource populations having poor access to eye care. While much is known regarding surgical access and outcomes, less is understood about the initial detection of operable cataracts in low-resource settings. We performed a comprehensive literature review on existing and emerging cataract screening methods in low- and middle-income countries (LMICs).

A NanoBiT assay to monitor membrane proteins trafficking for drug discovery and drug development.

Internalization of membrane proteins plays a key role in many physiological functions; however, highly sensitive and versatile technologies are lacking to study such processes in real-time living systems. Here we describe an assay based on bioluminescence able to quantify membrane receptor trafficking for a wide variety of internalization mechanisms such as GPCR internalization/recycling, antibody-mediated internalization, and SARS-CoV2 viral infection. This study represents an alternative drug discovery tool to accelerate the drug development for a wide range of physiological processes, such as cancer, neurological, cardiopulmonary, metabolic, and infectious diseases including COVID-19.