Role of COVID-19 in the Progression of Scleroderma Interstitial Lung Disease and New Onset Pulmonary Hypertension: A Challenging Case Report.

This case report describes an 80-year-old woman with systemic sclerosis (SSc), complicated by interstitial lung disease (ILD) and new-onset pulmonary hypertension (PH), likely triggered by an atypical SARS-CoV-2 infection. Diagnosed with SSc in 2016 and previously stable ILD, she experienced clinical deterioration in 2023 with worsening respiratory failure and PH. Despite negative PCR and antigen tests, high anti-SARS-CoV-2 IgG levels and CT findings were consistent with COVID-19-related organising pneumonia.

Efficacy and safety of mepolizumab in eosinophilic granulomatosis with polyangiitis: Insights from real-life cases and literature analysis.

Background And Aim: Recently, the MIRRA trial demonstrated the efficacy and safety of mepolizumab in refractory or relapsing eosinophilic granulomatosis with polyangiitis (EGPA) and the usefulness of this drug as a steroid-sparing agent. However, until now, only a few evidence is available about its effectiveness and safety in clinical practice. In this paper, we report our experience in the treatment of EGPA patients with mepolizumab in a real-world setting and review the current literature on this topic.