Histological interpretation of differentiated vulvar intraepithelial neoplasia (dVIN) remains challenging-observations from a bi-national ring-study.

Differentiated vulvar intraepithelial neoplasia (dVIN) is a premalignant lesion that is known to progress rapidly to invasive carcinoma. Accurate histological diagnosis is therefore crucial to allow appropriate treatment. To identify reliable diagnostic features, we evaluated the inter-observer agreement in the histological assessment of dVIN, among a bi-national, multi-institutional group of pathologists.

[A woman with a rash after bronchoscopy].

A 69-year-old woman underwent bronchoscopy because of a suspected lung tumour. Within 2 hours after bronchoscopy, the patient developed facial purpura. Based on clinical assessment and histopathological images, we established the diagnosis of post-bronchoscopy purpura.