The Formation of Chemical Degraders during the Conservation of a Wooden Tudor Shipwreck.

Determining the nature, evolution, and impact of acid-generating sulfur deposits in the Mary Rose wooden hull is crucial for protecting Henry VIII's famous warship for generations to come. Here, a comprehensive X-ray absorption near-edge spectroscopy (XANES) and X-ray fluorescence (XRF) study sheds vital light on the evolution of complex sulfur-based compounds lodged in Mary Rose timbers as a function of drying time. Combining insights from infrared spectroscopy correlates the presence of oxidized sulfur species with increased wood degradation via the loss of major wood components (holocellulose).

Satisfaction and Impact on Quality of Life of Clinical and Instrumental Surveillance and Prophylactic Surgery in BRCA-mutation Carriers.

Introduction: BRCA 1 and 2 mutation carriers are invited to follow intensive clinical and instrumental surveillance programs or are offered prophylactic breast and ovarian surgery. These recommendations impact many aspects of their life. This study aims to evaluate the satisfaction with surveillance and prophylactic surgery and the impact of these procedures on the quality of life.

Ovarian cancer in BRCA1 and BRCA2 gene mutation carriers: analysis of prognostic factors and survival.

Objectives: To compare clinical-pathological characteristics and outcome between sporadic ovarian cancer and ovarian cancer in patents with hereditary breast and ovarian cancer syndrome (HBOC).

Methods: Twenty-four patients with ovarian cancer treated between 2000 and 2009 who tested positive for BRCA1/2 mutation (BRCA+) and a control group of 64 age-matched patients with no family history of breast/ovarian cancer (controls) were enrolled. Clinical-pathological characteristics, surgical outcome, overall (OS), and progression-free survival (PFS) were compared between the two groups.