Offering Tailored Therapy for Patients with Benign Esophageal Strictures-A Tertiary Center Experience in Romania.

: Over the last two decades, therapy for benign esophageal strictures has shifted from empirical dilatations and surgery to evidence-based and complex endoscopic and surgical procedures, aiming to achieve long-term esophageal patency. Aim: The purpose of our study is to provide descriptive evidence regarding the appropriate tailored medical, endoscopic, and surgical management of benign esophageal strictures. : This retrospective study includes patients with benign esophageal strictures; the data collected encompass the complete patient profiles, detailed etiologic and anatomic workups of the strictures, comprehensive imaging, as well as management and follow-up details.

Strategic Management of Descemet's Membrane Perforation During DALK in Advanced Keratoconus.

Objective: To report on the surgical treatment of advanced keratoconus (KC) with stromal scarring in a young male patient with asymmetric disease progression complicated by an intraoperative microperforation of Descemet's membrane (DM) during deep anterior lamellar keratoplasty (DALK).

Methods: The surgical approach consisted of manual descemetic DALK (dDALK), further complicated with DM microperforation. Anterior segment ocular coherence tomography (AS-OCT) was used intraoperatively to locate the site and size of the tear.

Post-Pandemic Burden of COVID-19-Related Restrictions in the Management of Digestive Tract Cancers: A Single Center Study.

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has required a complete change in the management of patients with gastrointestinal disease who needed to undergo endoscopic procedures. In the second year of the COVID-19 pandemic, due to restrictions for elective endoscopic procedures, a large number of cancer patients were prevented from early diagnosis of several digestive cancers, which has led to a serious burden in the health system that now needs to be dealt with. We designed a prospective study that included patients in whom access to elective endoscopic examinations during the COVID-19 pandemic had been delayed.

Triple Antioxidant Therapy, an Alternative for Patients with Chronic Liver Disease - A Prospective Multicenter Interventional Study.

Non-alcoholic fatty liver disease (NAFLD) has increased exponentially in recent years in Western European countries, where the number of hepatitis of viral etiology has been declining, and it is thought to be the most common cause of chronic liver disease in the near future (1). Currently, NAFLD is both the second most common cause of hepatocellular carcinoma (HCC) and the second most common indication for liver transplantation (2-4). This problem is very serious, as cases of NAFLDs are increasingly in children, a population with a long life ahead, and in whom the disease has all the time to progress to cirrhosis and HCC (5, 6).

Is there a risk for lymphoma or extracolonic cancer in patients with inflammatory bowel disease?

An important issue in the management of inflammatory bowel disease (IBD) is the risk for lymphatic or extracolonic malignancies reported in patients receiving prolonged immunosuppressive therapy and/or therapies with biological agents. Azathioprine (AZA), 6-mercaptopurine (6-MP), methotrexate. and anti-TNF (infliximab, adalimumab) are reference drugs for IBD forms unresponsive to conventional therapies.

Extra-intestinal malignancies in inflammatory bowel disease: results of the 3rd ECCO Pathogenesis Scientific Workshop (III).

The incidence of lymphoproliferative disorders (LD) is increasing in developed countries. Patients with inflammatory bowel disease (IBD) exposed to thiopurines are at additional risk of three specific forms of LD: Epstein-Barr-Virus-related post-transplant like LD, hepato-splenic T-cell lymphoma and post-mononucleosis lymphoproliferation. The risk of the two latter forms of LD can be reduced when considering specific immunosuppressive strategies in young males.

Malignant tumors of digestive organs and liver metastases at the time of diagnosis.

Aim: Malignant tumors localized in the digestive tract have a tendency to local growth and invasion with lymph node metastasis. Distant metastases through blood with prevalent liver location are detected late in disease progression, in an advanced stage, when therapeutic possibilities are often limited to palliative therapy.

Material And Methods: The study included a series of 139 patients with liver metastases admitted to the Center of Gastroenterology and Hepatology lasi between January 1 and October 10, 2011 for the identification of primitive tumor.

[Correlational aspects of hematogenous osteomyelitis in children and adults].

Unlabelled: Osteomyelitis is an inflammation of the bone caused by an infecting organism. The infection may be limited to a single portion of the bone or may involve a number of regions such as the marrow, cortex, periostium and even the surrounding soft tissue.

Material And Method: This retrospective study included a number of 256 cases made by 152 children (56%) and 115 adults (44%).

[p-ANCA prevalence in ulcerative colitis patients and first-degree relatives].

Unlabelled: Perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) are more common in patients with ulcerative colitis (UC) than in patients with Crohn's disease (CD), but its prevalence depends on the population being studied and the method employed for its detection.

Aim: To determinate the prevalence of p-ANCA in ulcerative colitis (UC) patients and their first degree in NE Romania area.

Material And Method: In this study, we investigated the prevalence of p-ANCA as detected by ELISA, in the serum of 44 patients with UC and 22 first degree relatives.

[Clinical extraintestinal manifestations in patients with ulcerative colitis].

Unlabelled: Ulcerative colitis (UC) is a chronic disease clinically manifest either by bowel symptoms alone or extraintestinal symptoms.

Material And Method: Our prospective study included 635 patients with ulcerative colitis (334 males and 301 females, mean age 37.54 +/- 13.

[Role of video-capsule endoscopy in Crohn's disease].

Unlabelled: The technical and scientific improvements of the miniature electronic equipment made possible the occurrence of video-capsule endoscopy (VCE), which is a device having an enormous noninvasive investigation potential of the small intestine. One of the most attractive indications of VCE is the suspicion of Crohn's disease that has not been confirmed using standard imaging techniques.

Aim: To assess the value of VCE in the diagnostic work-up of patients in whom there is clinical suspicion of small bowel Crohn's disease that cannot be confirmed using conventional techniques (upper and lower endoscopy, small bowel follow-through).

[Clinical and epidemiological aspects in patients with colorectal cancer].

Unlabelled: The aim of this study was to evaluate the clinical factors of the patients with CCR histologically confirmed.

Patients And Methods: In the study group there were included 117 patients (females: 49-41%, males: 68-59%, range: 39-88 years) with CCR confirmed (rectosigmoidoscopy/colonoscopy + biopsy, X-ray) hospitalized in the Second Medical Clinic Gastroenterology during January 2000-May 2001.

Results: For 56 (47.