Concomitant Chronic Urticaria in Children: A Distinct Severe Phenotype.

Introduction: Chronic spontaneous urticaria (CSU) presents as repetitive spontaneous hives and/or angioedema lasting for at least six weeks. In contrast, chronic inducible urticaria (CIndU) is triggered by specific stimuli. This study aimed to characterize children who have concurrent CSU and CIndU excluding children with symptomatic dermographism, and to identify factors that distinguish them from children with CSU alone or CIndU alone.

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer.

Merkel cell carcinoma (MCC) is a highly aggressive disease with the poorest prognosis among skin cancers, originally posited to be derived from Merkel cells. Emerging evidence, however, suggests other potential origins for MCC, including hematological lineages. We utilized targeted and multi-omics approaches to explore gene expression patterns at protein and RNA levels of MCCs.

Global Approach for Severe Cutaneous Adverse Reactions (GRASS) Survey.

Background: Consensus guidelines outline the recommended management of delayed drug hypersensitivity reactions (DHR), but clinical practices are largely expert-based and may vary significantly across populations and regions. This study evaluated the approach and management of healthcare specialists globally regarding DHR, including severe cutaneous adverse reactions (SCARs).

Objective: To assess the current practices, knowledge, and availability of allergy testing for DHR, including SCARs, among relevant healthcare professionals globally.

A Comparison of Chronic Spontaneous Urticaria Clinical Characteristics and Management between Canadian and Israeli Adults.

Introduction: Chronic spontaneous urticaria (CSU) is increasingly recognized as a significant health issue with significant impacts on quality of life in adult populations. Data are sparse regarding differences in clinical characteristics and management of CU in different countries. We aimed to compare adult CU populations in Canada and Israel to identify demographic, clinical, and management differences.

Treatment of Hailey-Hailey disease with the Janus kinase inhibitor abrocitinib: A case report.

Hailey-Hailey disease is a rare, chronic, autosomal dominant skin disorder characterized by recurrent painful erosions and macerated plaques, primarily affecting intertriginous areas. It is caused by mutations in the gene, leading to impaired calcium homeostasis and keratinocyte adhesion. Many patients experience poor disease control despite conventional therapies.

Assessment of Quality of Life in Children with Chronic Urticaria Using the Children's Dermatology Life Quality Questionnaire Index: A Retrospective Cohort Study.

Introduction: Chronic urticaria (CU) negatively impacts children's quality of life (QoL), yet data on pediatric CU remain limited. This study assessed CU's impact on QoL using the Children's Dermatology Life Quality Index (CDLQI).

Methods: Children (4-16 years) with CU were recruited and completed standardized questionnaires on demographics, CU type, management, and comorbidities.

Successful treatment of localized scleroderma using brodalumab: A case report.

We report the first documented use of brodalumab, an IL-17 receptor antagonist, for treating severe linear localized scleroderma refractory to conventional therapies, including methotrexate, mycophenolate mofetil and corticosteroids. The patient demonstrated rapid and sustained improvement in disease activity and severity, highlighting the potential role of IL-17 signaling in the pathogenesis of localized scleroderma. This case supports further investigation of IL-17 pathway blockade in autoimmune fibrotic diseases.

Health-Related Quality of Life in Chronic Urticaria: A Systematic Review and Meta-Analysis.

Background: Chronic urticaria (CU), including chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU), significantly affect patients' health-related quality of life (HRQOL). To date, no systematic reviews or meta-analyses have summarized the HRQOL tools used in CU and the magnitude of HRQOL impact in CU.

Objective: To determine the HRQOL tools used in CU, the burden of CU regarding HRQOL in adults and children, and whether CU subtypes differentially affect HRQOL.

Incidence, prevalence, and mortality of localized scleroderma in Quebec, Canada: a population-based study.

Background: Localized scleroderma is an understudied autoimmune disease characterized by fibrosis of the skin and/or subcutaneous tissue. To date, only 6 articles reported on the incidence and/or prevalence estimates globally, with significant design limitations and risk of bias. None of the studies originated from Canada or investigated mortality/geospatial epidemiology.

Managing Chronic Urticaria in Children: An Update.

Purpose Of Review: To provide an update and new insights into the management of pediatric patients with chronic urticaria.

Recent Findings: Chronic urticaria in children may be more prevalent than previously thought, with a high resolution rate within two years. Patient-reported outcome measures (PROMs) are effective tools for assessing disease severity and control in pediatric populations.

Markers of Type 2 Inflammation and Immunosenescence Are Upregulated in Localized Scleroderma.

Localized scleroderma (LS) is an autoimmune, fibrotic skin disease that is thought to be triggered by environmental factors. Recent evidence from systemic autoimmune diseases proposed that the induction of immunosenescence may link environmental triggers with autoimmunity development. We aimed to explore the inflammatory signature in juvenile LS and investigate the presence of DNA instability and immunosenescence using publicly available transcriptomic data.

INDIVIDUAL ARTICLE: Real-World Cases of Clascoterone Topical Treatment for Acne and Related Disorders.

Acne vulgaris affects approximately 80% of young adults and adolescents in the world. Acne presents as comedones, pustules, papules, and nodules on the face, chest, shoulders, or back. It can lead to a significant decrease in quality of life with a high risk of associated depression and anxiety.

Cost-utility analysis of clinic-based deroofing versus local excision for hidradenitis suppurativa.

Background: Deroofing and local excision are common clinic-based surgical options for hidradenitis suppurativa. Evidence suggests deroofing may have lower rates of adverse events (AEs), defined as disease recurrence or postsurgical complications.

Objective: This cost-utility analysis evaluates the economic and health-related impacts of clinic-based deroofing vs excision for hidradenitis suppurativa, comparing direct medical costs and quality-adjusted life-years (QALYs).