Publications by authors named "Elan Shellard"
Characterising a Novel Therapeutic Target for Psoriasis, TYK2, Using Functional Genomics.
Int J Mol Sci
December 2024
Psoriasis (Ps) is a debilitating immune-mediated chronic skin condition. It affects about 1-3% of the world population, with an 8-11% prevalence in Northern European populations. Tyrosine kinase 2 (TYK2) is a newly identified target for Ps.
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- * Researchers developed models using T cells to analyze how different forms of IL23R (wild type vs. protective mutant) impact the signaling pathway via STAT3, identifying genes related to psoriasis risk through RNA sequencing.
- * The study discovered several key genes (like HLA-B, SOCS1, and CCR5) that are differentially regulated based on IL23R form, contributing to a better understanding of the IL23 pathway and its role in psoriasis.
Psoriasis is a lifelong, systemic, immune mediated inflammatory skin condition, affecting 1-3% of the world's population, with an impact on quality of life similar to diseases like cancer or diabetes. Genetics are the single largest risk factor in psoriasis, with Genome-Wide Association (GWAS) studies showing that many psoriasis risk genes lie along the IL-23/Th17 axis. Potential psoriasis risk genes determined through GWAS can be annotated and characterised using functional genomics, allowing the identification of novel drug targets and the repurposing of existing drugs.
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