Investigating the Relationship Between Semen Paraoxonase-3 Concentration, Sperm Parameters, and DNA Fragmentation in Fresh or Post-Thaw Semen of Normozoospermic Men.

Background: PON3 is associated with high-density lipoprotein (HDL) and plays a protective role against oxidative damage to low-density lipoprotein (LDL). The purpose of the current study was to investigate the effect of semen paraoxonase-3 (PON3) concentration on sperm parameters and DNA fragmentation in both fresh or post-thaw semen.

Methods: This study analyzed PON3 levels in 30 normospermic semen samples obtained from men who attended Dezful Infertility Center and provided informed consent.