Clinical and Procedural Characteristics of Patients Undergoing Endobronchial Ultrasound-Guided Transbronchial Mediastinal Cryobiopsy (CryoEBUS): A Descriptive Study in a Colombian Population.

Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy (CryoEBUS) is an emerging minimally invasive technique that provides larger, better-preserved samples compared to conventional needle aspiration, improving suitability for histopathological and molecular testing. This retrospective study aimed to characterize the clinical profile, procedural aspects, and diagnostic yield of CryoEBUS in patients undergoing biopsy for mediastinal lesions. Fifty-nine patients underwent CryoEBUS.

Performance study of a new diagnostic questionnaire for (Chronic obstructive pulmonary -disease) COPD with information on exposure to wood smoke, COPD-WS.

Background: To determine the diagnostic performance of a new questionnaire (COPD-WS) that considers also exposure to wood smoke for diagnosing Chronic Obstructive Pulmonary Disease (COPD) in a Colombian population.

Methods: A cross-sectional study was conducted with analysis of diagnostic tests in subjects with and without COPD. Clinical variables were selected based on their relevance to COPD diagnosis, including age, sex, smoking status, exposure to wood smoke, dyspnea, cough, chronic expectoration, and wheezing.

Association of hemodynamic and functional variables with pulmonary vasculopathy in lung transplant recipients living at high altitude: A retrospective study.

ObjectivePulmonary hypertension is a heterogeneous syndrome with diverse underlying etiologies. This study aimed to evaluate the association between preoperative hemodynamic parameters-assessed by right heart catheterization (RHC) and transthoracic echocardiography (TTE)-and histopathological findings in explanted lungs from transplant recipients residing at high altitude.MethodsWe conducted a retrospective analysis of lung transplant recipients with interstitial lung disease (ILD) who had available RHC and TTE data prior to transplantation.

Performance of objective cough measurement, diaphragmatic contraction velocity, and spontaneous breathing trial for predicting extubation success in critically ill patients stratified by BMI: A prospective multicentre study.

Background: The transition from Invasive mechanical ventilation (IMV) to spontaneous breathing, known as the weaning-process (WP), requires careful evaluation. In obese patients, WP may be compromised due to altered respiratory mechanics, increasing the risk of weaning failure.

Objective: to evaluate the predictive capacity of objective cough measurement (OCM), spontaneous breathing trial (SBT), and diaphragmatic contraction velocity (DCV) in predicting WP success in obese patients.

Association between oxygen debt (DEOx) variability over time and clinical outcomes in critically ill COVID-19 patients: an observational study.

Background: Oxygen debt (DEOx) quantifies oxygen deficit during shock, reflecting the transition to anaerobic metabolism due to decreased oxygen delivery (DO₂). This study aimed to analyze the temporal variation of DEOx values and their association with invasive mechanical ventilation (IMV) requirement and survival in patients with severe COVID-19.

Methods: We conducted a retrospective cohort study including adult patients admitted to the ICU with confirmed SARS-CoV-2 infection at Clínica Universidad de La Sabana (Colombia) between July 2020 and December 2021.

Optimizing diagnostic yield in pulmonary lesions: impact of combined sampling tools and EBUS-TBNA during radial EBUS.

Background: Radial endobronchial ultrasound (r-EBUS) is a minimally invasive procedure used to evaluate pulmonary lesions suspicious of cancer. Current information on the effect of combining different sampling tools used during r-EBUS or the addition of linear EBUS (EBUS-TBNA) on its diagnostic performance is limited.

Objectives: To evaluate the effect on diagnostic performance of the systematic addition of different sampling tools and EBUS-TBNA during r-EBUS, as well as the rate of peri-procedural complications.

Survival analysis in a high-altitude lung transplant program: insights from a real-life observational study.

Objective: Survival in lung transplantation (LT) may be influenced by recipient-related variables, donor factors, donor-recipient interaction, surgical approach, and medical center expertise. The objective of this study was to describe the sociodemographic, clinical characteristics, and survival of patients who have undergone LT.

Method: We conducted an observational analysis between 2014 and 2022.

Development and Validation of the Bronchoscope Quality Questionnaire for Assessing Bronchoscopists' Perception of Single-Use Flexible Bronchoscope Quality.

Introduction: The risk of cross-infections (including SARS-CoV-2) and damage to the flexible bronchoscope has led to the development of single-use flexible bronchoscopes as a cost-effective alternative. It is necessary for the bronchoscopist to evaluate the perception of the quality of these devices to determine if their quality is satisfactory for the user. The objective of this study was the construction and validation of a Bronchoscope Quality Questionnaire (BQQ) to evaluate the quality of the flexible bronchoscope perceived by the bronchoscopist.

Mapping the comorbidome: A novel analysis of the associations between obstructive sleep apnea and its comorbidities in Colombia.

IntroductionObstructive sleep apnea (OSA) is linked to a complex network of comorbidities, including cardiovascular, metabolic, neurological, and oncological diseases. The comorbidome visually maps disease associations, highlighting the interconnected comorbidities of OSA, whose incidence and severity are strongly correlated.MethodsA retrospective cohort study was conducted between 2005 and 2020 to identify the comorbidities most frequently associated with OSA through a comprehensive comorbidity map.

Survival rates at one and five years for patients with group 1 pulmonary arterial hypertension at high altitude: A retrospective cohort study.

ObjectivesGroup 1 pulmonary arterial hypertension (PAH) causes increased vascular resistance, right heart failure, and reduced survival. High-altitude PAH survival data are limited despite chronic hypoxia's potential impact on disease progression and risk stratification. The objective was to evaluate survival stratified by the European Society of Cardiology/European Respiratory Society (ESC/ERS) baseline risk score, REVEAL risk score 2.

Comparison of the Predictive Capacity of Oxygenation Parameters, Oxygenation Indices, and CURB-65 to Mortality, Mechanical Ventilation, and Vasopressor Support in Community-Acquired Pneumonia at Different Altitudes.

Populations residing at high altitudes display distinct physiological adaptations that are essential for understanding respiratory diseases. However, there is limited research on how these adaptations affect the assessment and prognosis of community-acquired pneumonia (CAP). A prognostic validation nested within a retrospective cohort was conducted on subjects with pneumonia admitted to two high-complexity institutions in Colombia at different altitudes above sea level.

Survival outcomes among hospitalized patients with dementia: a propensity score matching analysis.

Background: Hospitalized patients with dementia exhibit high mortality rates, underscoring the importance of investigating variables associated with reduced survival. This study aims to determine the incidence of dementia among hospitalized patients and survival rates at 1 and 3 years post-hospitalization.

Methods: A retrospective cohort study was conducted using administrative databases from the Ministry of Health of Colombia.

Impact of Pulmonary Hypertension on Posttransplant Survival of Patients With Pulmonary Fibrosis at High Altitude: A Prospective Cohort Study.

Pulmonary hypertension (PH) in patients undergoing lung transplantation (LT) for pulmonary fibrosis can impair lung function, reduce physical activity, and decrease survival. However, data on outcomes at 1 and 5 years of follow-up remain limited. In this prospective cohort study, pulmonary function, the 6-min walk test (6MWT), and the St.

Machine learning to predict extubation success using the spontaneous breathing trial, objective cough measurement, and diaphragmatic contraction velocity: Secondary analysis of the COBRE-US trial.

Introduction: Determining the optimal timing for extubation in critically ill patients is essential to prevent complications. Predictive models based on Machine Learning (ML) have proven effective in anticipating weaning success, thereby improving clinical outcomes.

Aim Of The Study: The study aimed to evaluate the predictive capacity of five ML techniques, both supervised and unsupervised, applied to the spontaneous breathing trial (SBT), objective cough measurement (OCM), and diaphragmatic contraction velocity (DCV) to estimate a favorable outcome of SBT and extubation in critically ill patients.

Role of the very low frequencies of the renal oxygen saturation signal in acute kidney injury in newborns with perinatal asphyxia.

Objective: Renal autoregulation, hemodynamic response, and endothelial dysfunction play significant roles in acute kidney injury (AKI) during perinatal asphyxia. A third mechanism of autoregulation, involving very low-frequency oscillations, has been described. This study aimed to evaluate the relationship between the power of the very low-frequency component of the Fast Fourier Transform (FFT) and AKI during therapeutic hypothermia (TH) treatment in neonates with perinatal asphyxia.

CAD-Q (COPD-Asthma Differentiation Questionnaire): Performance of a new diagnostic score to differentiate between COPD and asthma in adults.

Background: Chronic obstructive pulmonary disease (COPD) and asthma are the two most prevalent chronic respiratory diseases, significantly impacting public health. Utilizing clinical questionnaires to identify and differentiate patients with COPD and asthma for further diagnostic procedures has emerged as an effective strategy to address this issue. We developed a new diagnostic tool, the COPD-Asthma Differentiation Questionnaire (CAD-Q), to differentiate between COPD and asthma in adults.

Classification of Obstructive Pulmonary Diseases Through Clinical Characteristics in a Prospective Cohort Study.

Introduction: The use of clinical characteristics to differentiate obstructive lung diseases remains unclear, with limited supporting studies. This study aims to assess the effectiveness of signs and symptoms from clinical questionnaires in diagnosing obstructive lung diseases.

Methods: This prospective cohort study included patients diagnosed with chronic obstructive pulmonary disease (COPD), asthma, or asthma-COPD overlap (ACOS) based on spirometry.

Boosting the Beat: A Critical Showdown of Levosimendan and Milrinone in Surgical and Non-Surgical Scenarios: A Narrative Review.

Acute heart failure, advanced cardiac failure, cardiac surgery, and sepsis are conditions that require simultaneous treatment to stimulate contractility and/or reduce systemic vascular resistance, with levosimendan and milrinone being treatment options. This research's aim is to review the current indications and evidence for these medications across various scenarios. Evidence suggests that levosimendan is a non-inferior alternative to dobutamine and superior to milrinone in treating low cardiac output syndrome following cardiac surgery.

Comparison of performances between risk scores for predicting mortality at 30 days in patients with community acquired pneumonia.

Background: Risk scores facilitate the assessment of mortality risk in patients with community-acquired pneumonia (CAP). Despite their utilities, there is a scarcity of evidence comparing the various RS simultaneously. This study aims to evaluate and compare multiple risk scores reported in the literature for predicting 30-day mortality in adult patients with CAP.

Development of a web application to evaluate spirometric curve and clinical variables to support COPD diagnosis in primary care.

Introduction: Choric obstructive pulmonary disease (COPD) is the third mortality cause in the world, and the development of useful diagnostic tools is necessary to improve timely diagnostic rates in primary care settings.

Objective: To develop a web application displaying spirometric and clinical information - including respiratory symptoms and risk factors- to facilitate a COPD diagnosis.

Materials And Methods: In this cross-sectional study, an expert consensus was carried out with three specialists using the Delphi method to choose the relevant variables for COPD diagnosis.

Survival at 3, 6 and 12 months in patients diagnosed with community-acquired pneumonia in Colombia: a retrospective cohort study.

Background: The primary aim of this study is to assess the survival rates of individuals diagnosed with Community-Acquired Pneumonia (CAP) post-hospitalization in Colombia. Additionally, explore potential risk factors associated with decreased long-term survival.

Methods: A retrospective cohort study was conducted in a hospital in Colombia, evaluating survival at 3, 6 and 12 months in CAP patients, using the Kaplan-Meier method.