Publications by authors named "Eduardo D Paiva"
Article Synopsis
- Diabetic ulcers are challenging to heal due to increased human neutrophil elastase (HNE) secretion and bacterial infections. The study focused on creating electrospun fibers from polycaprolactone (PCL) and polyethylene glycol (PEG) that contain elastase-targeting peptides (AAPV and WAAPV).
- Characterization showed that WAAPV effectively inhibits HNE, and the addition of PEG helps control fiber degradation and allows for sustained peptide release over 24 hours.
- The peptide-loaded fibers demonstrated significant antibacterial effects against certain bacteria, inhibiting growth by up to 78%, offering promising strategies for treating diabetic ulcers.
Beta particles radiation doses have important applications in medicine. In particular, curved and symmetric as well as curved and asymmetric applicators containing the beta emitting Ru/ Rh isotopes are widely used in radiotherapy for the treatment of various ocular diseases. Nevertheless, a great problem in the use of these applicators is the inaccurate determination of the dose rates around them.
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