Publications by authors named "Edmond Differding"

A comprehensive analysis of 2165 projects funded by India's Department of Biotechnology since 2005 through private-public partnerships, and as of 2012 through the 'Biotechnology Industry Research Assistance Council (BIRAC)' until BIRAC's tenth anniversary at the end of March 2022 reveals details of the science and technology underpinning past and current biotechnology research and development projects in the country. They are led by human healthcare projects (74.9 % overall), of which medical technology (58.

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Drug discovery keeps evolving, as illustrated by the scientific programs of the European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry. The analysis of lecture topics over five decades reveals shifts in the importance given to therapeutic areas, treatment modalities, or technologies. All had an impact on the discipline of medicinal chemistry and contribute to a better understanding of the drug research industry as we know it today.

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A historical overview of key events that led, 50 years ago, to the foundation of the European Federation for Medicinal Chemistry (EFMC), and the impact this had on promoting and structuring medicinal chemistry as a discipline in Europe. EFMC, together with the growing number of newly established national medicinal chemistry societies or divisions, created the framework for networking and knowledge exchange. This includes organizing conferences, in particular its biennial 'International Symposium on Medicinal Chemistry (EFMC-ISMC)'.

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This review provides a comprehensive survey of proprietary drug discovery and development efforts performed by Indian companies between 1994 and mid-2016. It is based on the identification and detailed analysis of pharmaceutical, biotechnology, and contract research companies active in proprietary new chemical entity (NCE) research and development (R&D) in India. Information on preclinical and clinical development compounds was collected by company, therapeutic indication, mode of action, target class, and development status.

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Global pharmaceutical and biotechnology companies have been building increasingly on the skills and services offered by Indian biotech companies through strategic collaborative partnerships and alliances to fuel their in-house discovery and development pipelines. With the exception of generic press releases, however, very little has been published on the process and progress of drug discovery itself, such as the targets or modes of action involved, nor on the scientific output of such collaborations, and therefore on new chemical entities coming out of India through research collaborations. This Essay provides an analytical review of recent patents, patent applications, and peer-reviewed publications of major research alliances.

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Article Synopsis
  • Levetiracetam (Keppra) is a new medication approved for treating hard-to-control partial onset seizures in adults, showing good efficacy and tolerance due to its specific binding site in the brain.
  • Researchers aimed to discover new drugs targeting the levetiracetam binding site (LBS) by modifying the structure of the original compound, finding that certain modifications improved the drug's potency against seizures.
  • A promising drug candidate named ucb 34714 emerged from these modifications, showing to be ten times more effective than levetiracetam in mice and is set to enter phase II clinical trials.
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