Comparison of Two Activated Clotting Time Targets During Cardiac Surgery With Cardiopulmonary Bypass: A Prospective Multicenter Randomized Controlled Trial.

Objectives: The present study was designed to investigate the equivalence of two target activated clotting time (ACT) values with regard to packed red blood cell (PRBC) transfusion in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Secondary endpoints include postoperative blood loss, transfusion of other blood products, and postoperative laboratory parameters, including renal function, intensive care unit length of stay, postoperative thrombotic events, and other adverse events.

Design: Multicenter, randomized, single-blind, controlled equivalence trial.

Study protocol of the multicentre, randomised, triple-blind, placebo-controlled MERCURI-2 trial: promoting effective renoprotection in cardiac surgery patients by inhibition of sodium glucose cotransporter (SGLT)-2.

Introduction: Acute kidney injury (AKI) is a major complication after cardiac surgery and is associated with postoperative morbidity and mortality. Currently, no effective therapy exists to reduce the incidence of postoperative AKI. Sodium-glucose cotransporter-2 (SGLT2) inhibitors are effective in reducing AKI in outpatient settings for patients with chronic kidney disease.