Supporting qualitative practitioner research in child and adolescent mental health.

This editorial piece addresses the relationship between clinical practice and qualitative research in child and adolescent mental health. We outline some guiding assumptions informing the development of a practice orientated research 'lab' which focusses on child and adolescent mental health and child welfare research with ethnographic and psychosocial methodologies. We consider cascading effects of practitioner-initiated research, where skills and ambitions for a 'bottom up' research culture can help professionals embed research-minded practice in services.

Multifocal extramural venous invasion is a powerful predictor of adverse oncological outcomes in stages I-III colorectal cancer.

Aims: This study aimed to determine the impact of venous invasion (VI) characteristics on oncological outcomes in colorectal cancer (CRC).

Methods And Results: Resection specimens from 368 patients with TNM stages I-III CRC were assessed for VI including its presence/absence, location [intramural (IMVI) or extramural (EMVI)], number and size of the largest VI focus. VI and EMVI were identified in 55% and 32% of cases, respectively.

Knowledge, attitude and practices of primary livestock raisers regarding anthrax and anthrax vaccination of livestock in outbreak and non-outbreak areas of Bangladesh.

Anthrax is a zoonotic disease caused by the spore-forming bacterium Bacillus anthracis. Outbreaks are periodically reported among people and livestock in Bangladesh. From 2009-2020, approximately 4000 suspected human cutaneous anthrax cases were reported.

Development of an All-Hydrocarbon Stapled Peptide Targeting BRK1 in Triple-Negative Breast Cancer.

Wiskott-Aldrich syndrome protein family (WASF) members are key regulators of actin cytoskeleton dynamics at the leading edge of the cell membrane. WASF3 has been demonstrated to directly promote cancer invasion and metastasis in triple-negative breast cancer. WASF3 is incorporated into a heteropentameric protein complex with BRK1, CYFIP1/2, NCKAP1/1L, and ABI1/2/3 termed the WASF Regulatory Complex (WRC) that links upstream signaling pathways to Arp2/3-mediated actin nucleation.