Publications by authors named "Drake Palmer"
Malignant pleural mesothelioma (MPM), an aggressive cancer of the mesothelial cells lining the pleural cavity, lacks effective treatments. Multiple somatic mutations and copy number losses in tumor suppressor genes (TSGs) , , and are frequently associated with MPM. The impact of single versus multiple genomic alterations of TSG on MPM biology, the immune tumor microenvironment, clinical outcomes, and treatment responses are unknown.
View Article and Find Full Text PDFCancer is a disease of gene dysregulation, where cells acquire somatic and epigenetic alterations that drive aberrant cellular signaling. These alterations adversely impact transcriptional programs and cause profound changes in gene expression. Interpreting somatic alterations within context-specific transcriptional programs will facilitate personalized therapeutic decisions but is a monumental task.
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- ATR kinase plays a vital role in managing DNA damage responses and cell cycle checks, and its inhibitors (ATRi's) enhance CD8 T cell responses when combined with radiation in cancer models.
- ATRi's trigger CDK1-dependent DNA replication processes in CD8 T cells while reducing key enzymes needed for nucleotide production, leading to genomic issues like dU contamination and R loops.
- Thymidine can counteract some of the harmful effects caused by ATRi's, suggesting that controlling dU contamination is crucial for reducing side effects in cancer treatment and improving T cell anti-tumor responses.
Purpose: Human papillomavirus (HPV) infection drives the development of some head and neck squamous cell carcinomas (HNSCC). This disease is rapidly increasing in incidence worldwide. Although these tumors are sensitive to treatment, approximately 10% of patients fail therapy.
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