Publications by authors named "Doerte Langemann"
Article Synopsis
- Scientists investigated how the Smac mimetic LCL161 boosts the effectiveness of chemotherapy in neuroblastoma by targeting inhibitor of apoptosis proteins.
- The combination of LCL161 and the chemotherapy drug vincristine (VCR) led to enhanced cell death, through the activation of various apoptotic pathways, although the specific signaling mechanisms are still not well understood.
- Notably, the activation of NF-κB and TNF-α signaling was found to have little impact on the apoptosis induced by VCR and LCL161, suggesting that other pathways are primarily responsible for the observed effects.
Neuroblastoma is the most common extracranial solid tumor during infancy and childhood.Outcome of high-risk and late-stage disease remains poor despite intensive treatment regimens.Suppressing inhibitor of apoptosis proteins (IAPs) using Smac mimetics (SM) significantly sensitizes neuroblastoma (NB) cells for chemotherapy, however strongly dependent on the cytotoxic drug combined with SM.
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