Promising role of dietary microalgae blend in alleviating the heat stress draw backs in broiler chickens: Impact on performance, meat antioxidants and fatty acids content and expression of heat shock protein and sirtuins related genes.

Adopting innovative nutritional strategies, such as microalgae blend supplementation, can help reduce the detrimental effects of heat stress (HS) in poultry farming. This study was designed to explore the effects of different dietary levels of microalgae blend containing nannochloropsis oculate, schizochytrium and amphora coffesformis on modulating growth performance, muscle's antioxidant status, lipid profile and the expression of heat shock proteins and sirtuins family related genes in heat-stressed chicks. A total of 250 one-day-old chicks were randomly assigned to five experimental groups, with five replicates of 10 birds each: a control group reared under normal environmental conditions and fed a basal diet; HS group exposed to heat stress and fed a basal diet; and three HS groups supplemented with a microalgae blend at 2.

Optimistic effects of dual nano-encapsulated probiotics on breeders laying performance, intestinal barrier functions, immunity and resistance against Salmonella Typhimurium challenge.

Dual nano encapsulation of multi-strain probiotic bacteria can enhance their viability within the avian gastrointestinal tract and improve their effectiveness in disease prevention. So that this study spotted the light on the effect of dual nano encapsulated multi strain of probiotics (LEBB-NPs) contained Enterococcus faecium NCTC 7171, Bacillus amyloliquefaciens probiotic CECT 5940, Lacticasei bacillus casei ATTC334 and Bifidobacterium breve JCM1192 on laying performance, egg quality, immune defence, and resistance against Salmonella Typhimurium challenge. A total of 250 Ross 308 laying breeder hens, 20 weeks of age, were randomly allocated into five experimental groups (five replicates per group; 10 hens per replicate).

The Potential Effect of Dapagliflozin and Liraglutide in Attenuating Cardio-Renal Injuries in Diabetic Rats.

Objective: To evaluate the therapeutic benefits of dapagliflozin and liraglutide as treatments for type 2 diabetes mellitus and their combined effects on T2DM-related complications, specifically cardio-renal injury.

Methods: Thirty rats were randomly allocated into two groups, with the first group serving as the control group, which had 6 rats. The second group was the experimental group, which had 24 rats administered a high-fat diet for four weeks, followed by a single dose of streptozotocin (STZ) to induce diabetes mellitus (DM).

Perspectives approaches using dietary glutamine and L-carnitine toward enhancement of reproductive performance of breeding pigeons and coordination of Genes controlling nutrients transport, lipogenesis and myogenesis in hatched squabs.

Large-scale production of squabs necessitates good planning of nutritional regimen comprising novel feed additives that boost their production. Herein, the combined impact of dietary glutamine and L-carnitine was evaluated on breeding pigeons' reproductive performance and squab's productive performance, profitability, antioxidants and quantifying expression of myogenic, nutrient transporters and lipogenesis related genes. Six-month-old Baladi pigeons (100 pairs) were divided into four treatments, control, Glutamine, L-carnitine and Glut@L-carnitine groups which were fed basal diet fortified with 5 gm/kg diet Glutamine, 60 mg kg diet L-carnitine or combined Glutamine and L-carnitine with the same levels.

Correction: Hegazy et al. Terazosin Interferes with Quorum Sensing and Type Three Secretion System and Diminishes the Bacterial Espionage to Mitigate the Typhimurium Pathogenesis. 2022, , 465.

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Therapeutic application of nano-encapsulated pomegranate peel extract attenuated DSS-induced colitis: Antioxidant and anti-inflammatory role and reduction of exaggerated response of endoplasmic reticulum stress.

The medicinal application of pomegranate peel extract enriched with polyphenols (PPE) as a therapeutic strategy for managing inflammatory bowel diseases (IBD) is still limited. Integrating pomegranate peel extract (PPE) into an effective nanocarrier system could enhance its mechanistic actions, potentially aiding in the remission of colitis. Therefore, this approach aimed to enhance PPE's stability and bioavailability and investigate mitigating impact of pomegranate peel extract-loaded nanoparticles (PPE-NPs) in a colitis model.

Combined modulatory effects of dietary arginine and olive leaf phenolic extract on growth performance and immune functions of broiler chickens, and meat antioxidant potential during frozen storage.

Background: Nowadays, broilers reared in intensive farming become more susceptible to oxidative stress, which impairs their performance and the quality of their products. Arginine (G) is a crucial amino acid for chickens and feeding on arginine beyond the recommended levels has been shown to positively impact the growth performance of broiler chickens and their immunity. Olive leaves phenolic extract (OLE) is a natural source of powerful antioxidants.

Community pharmacists' knowledge and experience regarding malaria management: a cross-sectional study in Hodeida, Yemen.

Background: Malaria remains a significant public health concern in Yemen, ranking fourth in incidence within the Eastern Mediterranean Region. Community pharmacists play a pivotal role in malaria management and often dispense anti-malarial medications without prescriptions. However, little is known about their knowledge and adherence to the National Policy for Antimalarial Drugs.

Leaves Powder Mitigates Imidacloprid-Induced Neurobehavioral Disorders and Neurotoxic Reactions in Broiler Chickens by Regulating the Caspase-3/Hsp70/PGC-1α Pathway.

This study investigated the potential neuroprotective role of leaf powder (MOLP) dietary supplementation on imidacloprid (IMD)-induced neurobehavioral disturbances, oxidative stress, and apoptosis in broiler chicken brains. In a 6 week trial, 150 day-old commercial meat-type Ross 308 broiler chicks were randomly divided into five equal groups of 30 chicks each. The control and MOLP groups were fed a basal diet and a basal containing diet 25 g MOLP/kg, respectively, for 6 weeks.

Protective Role of Nano-encapsulated Bifidobacterium breve, Bacilllus coagulans, and Lactobacillus plantarum in Colitis Model: Insights Toward Propagation of Short-Chain Fatty Acids and Reduction of Exaggerated Inflammatory and Oxidative Response.

Irritable bowel disease (IBD), also known as ulcerative colitis and Crohn's disease, is a chronic inflammatory disorder affecting millions of people worldwide. Herein, nano-encapsulated multi-strain probiotics formulation, comprising Bifidobacterium breve DSM24732 and B. coagulans SANK 70258 and L.

Report of a Rare Case of Acute Abdominal Pain Post-partum: Spontaneous Ureteral Rupture.

Spontaneous ureteral rupture is a rare cause of acute abdominal pain, particularly unusual during pregnancy or the post-partum period. While pregnancy-related changes like ureteral compression and dilation may play a role, no definitive mechanisms have been established. Clinicians should suspect ureteric injury in post-partum patients with free pelvic fluid.

High-intensity versus low-level laser therapy in treatment of patients with subacromial impingement syndrome: a randomized, double-blind, controlled trial.

To compare the effects of High-Intensity Laser Therapy (HILT) versus Low-Level Laser Therapy (LLLT) on shoulder pain and disability, shoulder Range of Motion (ROM), Pain Pressure Threshold (PPT), and sleep quality of patients having Subacromial Impingement Syndrome (SAIS). Forty-two patients with SAIS were randomly assigned into three groups, the HILT group (n = 14), the LLLT group (n = 14), and control group (n = 14). All groups received an exercise program consisted of shoulder muscles stretching and strengthening exercises.

Silver nanoparticles loaded with pomegranate peel extract and hyaluronic acid mediate recovery of cutaneous wounds infected with .

Smart innovative nanocomposites based on active ingredients and metallic nanoparticles with effective wound healing and antifungal properties are efficient in overcoming the limitations of traditional therapeutic products. Open wounds provide an ideal niche for colonization by () which poses substantial global health issues owing to delayed wound healing and disordered healing mechanisms. Therefore, proficient innovative therapies that control infection and promote wound healing are of imperative importance for the management of wounds and prevention of infection and possible complications.

Awareness of breast cancer and perceived barriers to breast screening methods: a community based cross-sectional study among women in Yemen.

Background: In Yemen, effective early detection and a comprehensive grasp of breast cancer symptoms and risk factors are vital in preventing its potentially deadly spread. However, challenges arise in combating breast cancer in Yemen due to the lack of patient registries, national strategies, and structured cancer treatment plans.

Objective: This research sought to evaluate the awareness levels of breast cancer and the perceived obstacles to breast cancer screening among adult Yemeni women.

Liposome encapsulating pine bark extract in Nile tilapia: Targeting interrelated immune and antioxidant defense to combat coinfection with Aeromonas hydrophila and Enterococcus faecalis.

Application of smart delivery systems for encapsulation of natural ingredients provides novel avenues and is being frequently developed. Thus, we aimed to highlight the effects of cyclosome liposomal pine bark extract (CL-PBE) on Nile tilapia growth, immunomodulation, antioxidant capacity and resistance against coinfection with Aeromonas hydrophila and Enterococcus faecalis and their associated virulence genes. The experiment was conducted on four fish groups receiving a control diet (control) along with three baseline meals supplemented with 200, 400 and 600 mg/kg diet of CL-PBE (CL-PBE 200, 400 and 600, respectively).

Enhancing impact of dietary nano formulated quercetin on laying performance: egg quality, oxidative stability of stored eggs, intestinal immune and antioxidants related genes expression.

Background: Nutritional interventions with natural antioxidants can provide a pragmatic solution for modifying hens' performance and maintaining oxidative stability of eggs during storage. Quercetin is the most abundant flavonoids with potent antioxidant and immune stimulant activities. The concept of incorporating of quercetin, as potent antioxidant and immunostimulant, into effective nano-carriers (QNPs) has promoted their bioavailability and stability thus, their effectiveness for the first time were assessed on laying hens' performance and immunity, eggs quality during storage.

Exploring the interactive impacts of citronellol, thymol, and trans-cinnamaldehyde in broilers: moving toward an improved performance, immunity, gastrointestinal integrity, and Clostridium perfringens resistance.

Aims: This study aimed to explore the effectiveness of dietary citronellol, thymol, and trans-cinnamaldehyde (CTC) essential oils blend on broilers' growth performance, immunity, intestinal microbial count, gut integrity, and resistance against Clostridium perfringens utilizing the necrotic enteritis (NE) challenge model.

Methods And Results: A total of 200 Ross 308 male broiler chicks received either a control diet or diet supplemented with three graded levels of CTC blend, including 300, 600, and 900 mg of CTC blend/kg diet and experimentally infected with C. perfringens strain at 23 days of age.

Efficacy of Leflunomide Compared to Methotrexate in the Treatment of Moderate to Severe Plaques Psoriasis: A Randomized Controlled Clinical Trial.

Introduction: Psoriasis is a chronic inflammatory autoimmune skin disease. Several treatment options are available including topical and systemic options. Methotrexate was the main systemic medication in treating severe psoriasis, yet adverse events can limit its use.

Phage-resistant Streptomyces abietis and its telomycin bioactive metabolite as a possible alternative to antibiotics.

Multidrug-resistant pathogens are now thought to be the primary global causes of disease and death. Therefore, it is imperative to develop new effective bioactive compounds from microbial sources, such as Streptomyces species. Nevertheless, the pharmaceutical industry suffered financial losses and low-quality end products as a result of Streptomyces bacteriophage contamination.

Insights of early feeding regime supplemented with glutamine and various levels of omega-3 in broiler chickens: growth performance, muscle building, antioxidant capacity, intestinal barriers health and defense against mixed infection.

Early nutritional management approach greatly impacts broilers' performance and resistance against coccidiosis. The current study explored the impact of post-hatch feeding with a combination of glutamine (Glut) and different levels of omega-3 on broiler chickens' growth performance, muscle building, intestinal barrier, antioxidant ability and protection against avian coccidiosis. A total of six hundred Cobb 500 was divided into six groups: first group (fed basal diet and unchallenged (control) and challenged (negative control, NC) groups were fed a basal diet without additives, and the other groups were infected with and supplemented with 1.

Evaluation of clinicians' knowledge and practice regarding pharmacotherapy of Non-Hodgkin's lymphoma: A multi-center study in Yemen.

Non-Hodgkin lymphoma (NHL) is a hematological malignancy that requires effective pharmacotherapy for optimal management. There is limited information regarding Yemeni clinicians' knowledge and practice of NHL pharmacotherapy. This study aims to assess the knowledge and practice of physicians and nurses in Yemen regarding pharmacotherapy of NHL.

Evaluation of Antiemetic Consistency in Chemotherapy-Induced Nausea and Vomiting Among NHL Patients in Sana'a, Yemen.

Background: Chemotherapy-induced nausea and vomiting (CINV) is a prevalent and distressing adverse effect that can negatively affect a patient's quality of life and treatment adherence.

Purpose: This study aimed to evaluate the consistency of antiemetic use with standard guidelines and to examine the factors influencing it.

Methods: This cross-sectional study was conducted at the National Oncology Center (NOC) of Al-Jomhouri Teaching Hospital, Sana'a, Yemen, from November 2022 to September 2023.