Association of Mast Cell Activity With Chronic Gingivitis, Chronic Periodontitis, and Aggressive Periodontitis in Adults: A Histochemical Observational Study.

Introduction: Periodontal diseases, including chronic gingivitis, chronic periodontitis, and aggressive periodontitis, are driven by complex immune responses, with mast cells (MCs) playing a pivotal role through the release of mediators during degranulation. Although MC involvement in chronic periodontal conditions has been documented, its role in aggressive periodontitis and the relationship between MC degranulation and inflammation intensity remain poorly understood. This study aimed to quantify MCs and assess their degranulation in gingival tissues across healthy gingiva, chronic gingivitis, chronic periodontitis, and aggressive periodontitis using histochemical staining to elucidate their role in periodontal inflammation and disease progression.

Expression of P53 Protein and Ki-67 Antigen in Oral Leukoplakia with Different Histopathological Grades of Epithelial Dysplasia.

Aims And Objective: The aim of this study is to investigate the expression of p53 protein and Ki-67 antigen in normal oral mucosa and oral leukoplakia with different grades of dysplasia using immunohistochemistry and to clarify the correlation of the expression of these cell cycle regulatory proteins.

Materials And Methods: A total of 20 archival tissue blocks obtained from our department which were diagnosed as mild ( = 5), moderate ( = 5), and severe dysplasia ( = 5) with normal mucosa ( = 5) as a control. Positivity of Ki-67 and p53 was analyzed using Statistical Package for the Social Sciences (IBM Corp.

Computer-assisted morphometric image analysis of cells of normal oral epithelium and oral squamous cell carcinoma.

Context: Oral squamous cell carcinoma (OSCC) is a malignant neoplasm of epithelial tissue origin. OSCC is traditionally graded into well, moderate and poorly differentiated. The assessment of cellular and nuclear features is very important in the histological grading of OSCC.