Publications by authors named "Dinh Dat Vu"
A scanning acoustic microscopy (SAM) system is a common non-destructive instrument which is used to evaluate the material quality in scientific and industrial applications. Technically, the tested sample is immersed in water during the scanning process. Therefore, a robot arm is incorporated into the SAM system to transfer the sample for in-line inspection, which makes the system complex and increases time consumption.
View Article and Find Full Text PDFYb-Gd Codoped Hydroxyapatite as a Potential Contrast Agent for Tumor-Targeted Biomedical Applications.
ACS Biomater Sci Eng
August 2023
Article Synopsis
- Recent advancements in nanomaterials, specifically hydroxyapatite (HAp) doped with rare-earth elements like Yb and Gd, have shown promise for bioimaging applications due to improved bioactivity and imaging properties.
- The synthesis of Yb-Gd-HAp nanoparticles involved a wet precipitation method, followed by characterizing them for crystal structure, functional groups, and surface area, alongside the development of an imaging contrast agent by conjugating with IR783 dye and folic acid.
- In vitro studies confirmed the biocompatibility of the nanoparticles, and photodynamic therapy was tested on MDA-MB-231 breast cancer cells, demonstrating effective photosensitizing properties and reactive oxygen species generation.
In this study, we report an advanced fabrication technique to develop a miniature focused needle transducer. Two different types of high-frequency (100 MHz) transducers were fabricated using the lead magnesium niobate-lead titanate (PMN-0.3PT) and lithium niobate (LiNbO) single crystals.
View Article and Find Full Text PDFFluorescence conjugated nanostructured cobalt-doped hydroxyapatite platform for imaging-guided drug delivery application.
Colloids Surf B Biointerfaces
June 2022
Article Synopsis
- * Using a co-precipitation approach, researchers created Co-HAp by replacing calcium ions with cobalt, and various techniques were applied to confirm the successful doping and characterize the nanoparticles.
- * Results showed that Co-HAp nanoparticles are non-toxic to breast cancer cell lines, have high drug loading capacity for doxorubicin (DOX), and exhibit enhanced fluorescence properties, making them suitable for drug delivery and imaging applications.
Imaging modalities combined with a multimodal nanocomposite contrast agent hold great potential for significant contributions in the biomedical field. Among modern imaging techniques, photoacoustic (PA) and fluorescence (FL) imaging gained much attention due to their non-invasive feature and the mutually supportive characteristic in terms of spatial resolution, penetration depth, imaging sensitivity, and speed. In this present study, we synthesized IR783 conjugated chitosan-polypyrrole nanocomposites (IR-CS-PPy NCs) as a theragnostic agent used for FL/PA dual-modal imaging.
View Article and Find Full Text PDFIn this study, a photoacoustic microscopy (PAM) system based on a multifocal point (MFP) transducer was fabricated to produce a large depth-of-field tissue image. The customized MFP transducer has seven focal points, distributed along with the transducer's axis, fabricated by separate spherically-focused surfaces. These surfaces generate distinct focal zones that are overlapped to extend the depth-of-field.
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