Identification of UDP-Glucuronosyltransferase mRNA in human platelets: differential levels in smokers and non-smokers.

Background: UDP-glucuronosyl transferases (UGTs) are major enzymes of phase II drug metabolism, yet their expression in human platelets remains underexplored. Objectives: This study aimed to characterize the mRNA expression profile of UGT isoforms in human platelets and to assess differences between cigarette smokers and nonsmokers.

Methods: Total RNA was extracted from platelet-rich plasma (PRP), buffy coat (BC), and liver samples.