Occurrence of per- and polyfluoroalkyl substances, pesticides, pharmaceuticals, and heavy metals in Greek backyard chicken eggs and estimation of the consumption risk.

Backyard chicken eggs are widely consumed worldwide, while they are also used as pollution bio-indicators for different groups of chemicals. In this study, home-produced eggs were collected from 17 chicken coops around Greece and analyzed for 46 per- and polyfluoroalkyl substances (PFAS), heavy metals, pesticide, and pharmaceutical residues. The number of PFAS detected per sample ranged from 17 to 24, while the mean concentration of ΣPFAS was 7.

Study on the fate of per- and polyfluoroalkyl substances during thermophilic anaerobic digestion of sewage sludge and the role of granular activated carbon addition.

Limited information is available on the removal of per- and polyfluoroalkyl substances (PFAS) in anaerobic digestion (AD). Τhe fate of six PFAS was studied in thermophilic bioreactors in the presence of granular activated carbon (GAC) and voltage application. Reactors with GAC exhibited lower concentrations of volatile fatty acids and higher methane production compared to those with and without the application of voltage.

New Pyridine Dicarbene Pincer Ligands with Ring Expanded NHCs and their Nickel and Chromium Complexes.

The pincer complexes [NiBr(CNC)]Br (4), [CrBr(CNC)] (5 a) and [CrBrCl(CNC)] (5 b), where CNC=3,3'-(pyridine-2,6-diyl)bis(1-mesityl-3,4,5,6-tetrahydropyrimidin-2-ylidene), were obtained from the novel ligand CNC, generated in situ from the precursor (CHNCH)Br and [NiBr(PPh)] or from [Cr{N(SiMe)}(THF)] and (CHNCH)Br by aminolysis, respectively. The tetrahedrally distorted square planar (τ≅0.30) geometry and the singlet ground state of Ni in 4 were attributed to steric constraints of the CNC backbone.

-(2-Aminophenyl)-benzamide Inhibitors of Class I HDAC Enzymes with Antiproliferative and Antifibrotic Activity.

Inhibitors of histone deacetylases (HDACs) have received special attention as novel anticancer agents. Among various types of synthetic inhibitors, benzamides constitute an important class, and one is an approved drug (chidamide). Here, we present a novel class of HDAC inhibitors containing the -(2-aminophenyl)-benzamide functionality as the zinc-binding group linked to various cap groups, including the amino acids pyroglutamic acid and proline.

Co-assembled MoS-TiO Inverse Opal Photocatalysts for Visible Light-Activated Pharmaceutical Photodegradation.

Heterostructured photocatalytic materials in the form of photonic crystals have been attracting attention for their unique light harvesting ability that can be ideally combined with judicious compositional modifications toward the development of visible light-activated (VLA) photonic catalysts, though practical environmental applications, such as the degradation of pharmaceutical emerging contaminants, have been rarely reported. Herein, heterostructured MoS-TiO inverse opal films are introduced as highly active immobilized photocatalysts for the VLA degradation of tetracycline and ciprofloxacin broad-spectrum antibiotics as well as salicylic acid. A single-step co-assembly method was implemented for the challenging incorporation of MoS nanosheets into the nanocrystalline inverse opal walls.

Synthesis of novel 2-pyrrolidinone and pyrrolidine derivatives and study of their inhibitory activity against autotaxin enzyme.

Autotaxin (ATX), a glycoprotein (~125 kDa) isolated as an autocrine motility factor from melanoma cells, belongs to a seven-membered family of ectonucleotide pyrophosphatase/phosphodiesterase (ENPP), and exhibits lysophospholipase D activity. ATX is responsible for the hydrolysis of lysophosphatidylcholine (LPC) to produce the bioactive lipid lysophosphatidic acid (LPA), which is upregulated in a variety of pathological inflammatory conditions, including fibrosis, cancer, liver toxicity and thrombosis. Given its role in human disease, the ATX-LPA axis is an interesting target for therapy, and the development of novel potent ATX inhibitors is of great importance.