Enhancing student well-being and focus: The role of playful study design and strengths use.

Although students' proactive behaviors are known to positively impact their performance, the mechanisms and conditions shaping this relationship remain largely unexplored and not well understood. In the present study, using proactivity theory as an overarching framework, we propose that two forms of proactive behaviors - strengths use and playful study design - may enhance students' flow experiences. In turn, student's flow is hypothesized to be positively associated with subsequent attentional outcomes.

Disentangling the effects of task difficulty and effort on flow experience.

Flow, which is a rewarding state of full focus, typically arises when engaging in tasks with an optimal level of difficulty that is matched with a person's skill level. Meanwhile, optimal task difficulty usually comes with the greatest effort exertion. We propose that not only the difficulty level, but also the level of effort invested plays a role in the subjective feelings of flow.

A Prospective Study on the Association of Parental and Peer Attachment and the General Factor of Personality.

Introduction: Personality traits covary to form a general factor of personality (GFP). The association of parental and peer attachment across adolescence and into early adulthood with the GFP in early adulthood were examined.

Methods: Data from the Oregon Youth Study were used in the analyses.

Molecular Characterization of a Rare ESBL E. coli Strain Causing a Necrotizing Enterocolitis Outbreak in Preterm Infants.

Background: Necrotizing enterocolitis (NEC), a severe comorbidity of prematurity, is usually sporadic, but occasional outbreaks suggest an infectious cause. Escherichia coli, the most frequent Gram-negative pathogen in preterm infants, historically displays a low inhospital transmissibility.

Aim: To report the management of an NEC outbreak in a Belgian neonatal intensive care unit and the molecular characterization of a rare, highly virulent/resistant E.

Predicting Leadership Status Through Trait Emotional Intelligence and Cognitive Ability.

Many interconnected factors have been implicated in the prediction of whether a given individual occupies a managerial role. These include an assortment of demographic variables such as age and gender as well as trait emotional intelligence (trait EI) and cognitive ability. In order to disentangle their respective effects on formal leadership position, the present study compares a traditional linear approach in the form of a logistic regression with the results of a set of supervised machine learning (SML) algorithms.

The neuroscientific basis of flow: Learning progress guides task engagement and cognitive control.

People often strive for deep engagement in activities, a state typically associated with feelings of flow - full task absorption accompanied by a sense of control and enjoyment. The intrinsic factors driving such engagement and facilitating subjective feelings of flow remain unclear. Building on computational theories of intrinsic motivation, this study examines how learning progress predicts engagement and directs cognitive control.

Population pharmacokinetics and dosing simulations of temocillin in liver-transplanted paediatric patients: a prospective, open-label, non-randomized study.

Objectives: Temocillin is a β-lactam antibiotic used for preventing or treating bacterial infections in liver-transplanted children. We characterized its pharmacokinetics in plasma and ascitic fluid and proposed dosing regimens that maximize the achievement of effective drug exposures in this patient group.

Methods: Patients aged 6-36 months received 25 mg/kg/12 h (n = 14) or 25 mg/kg/8 h (n = 23).

Case report: Personalized triple phage-antibiotic combination therapy to rescue necrotizing fasciitis caused by Panton-Valentine leukocidin-producing MRSA in a 12-year-old boy.

Maximal standard-of-care (SOC) management could not stop the life-threatening progression of a necrotizing fasciitis induced by Panton-Valentine Leukocidin-producing Methicillin-Resistant (MRSA) in a 12-year-old boy. Multi-route phage therapy was initiated along with antibiotics against and , eventually leading to full recovery with no reported adverse events.

Dose optimization of β-lactam antibiotics in children: from population pharmacokinetics to individualized therapy.

Introduction: β-Lactams are the most widely used antibiotics in children. Their optimal dosing is essential to maximize their efficacy, while minimizing the risk for toxicity and the further emergence of antimicrobial resistance. However, most β-lactams were developed and licensed long before regulatory changes mandated pharmacokinetic studies in children.

Phage-Mediated Digestive Decolonization in a Gut-On-A-Chip Model: A Tale of Gut-Specific Bacterial Prosperity.

Infections due to antimicrobial-resistant bacteria have become a major threat to global health. Some patients may carry resistant bacteria in their gut microbiota. Specific risk factors may trigger the conversion of these carriages into infections in hospitalized patients.

SARS-CoV-2 Infection in Children Less Than Forty Days Hospitalized in Belgium Between 2020 and 2022.

Our study aimed to assess the severity of severe acute respiratory syndrome coronavirus 2 infection in hospitalized infants under 40 days old, across 21 Belgian hospitals between 2020 and 2022. Of the 365 infants studied, 14.2% needed respiratory support.

Correction: Enhanced cardiac vagal tone in mental fatigue: Analysis of heart rate variability in Time-on-Task, recovery, and reactivity.

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Change in heart rate variability with increasing time-on-task as a marker for mental fatigue: A systematic review.

Fatigue-specific changes in the autonomic nervous system are often assumed to underlie the development of mental fatigue caused by prolonged cognitive tasks (i.e. Time-on-Task).

Gen Z and HIV-Strategies for Optimizing the Care of the Next Generation of Adolescents Living with HIV.

The management of adolescents living with HIV represents a particular challenge in the global response to HIV. The challenges specific to this age group include difficulties engaging and maintaining them in care, challenges with transition to adult care, and limited therapeutic options for treatment-experienced patients, all of which have been jeopardized by the COVID-19 pandemic. This paper summarizes some of the challenges in managing adolescents living with HIV, as well as some of the most recent and innovative therapeutic approaches in this population.

Revisiting the link between the sustained attention to response task (SART) and daily-life cognitive failures.

In this study, we examined the relationship betweenerrors of commissionon theSustained Attention to Response Task(SART)andscores on the Cognitive Failures Questionnaire (CFQ). The goal was to assess theecological validity of the SARTin a sample of people scoring high on fatigue complaints.SART errors of commission were positively associated with CFQ scores and this finding remained after controlling for fatigue level, age, and SART reaction times.

Probiotics for children with uncomplicated severe acute malnutrition (PruSAM study): A randomized controlled trial in the Democratic Republic of Congo.

Background: Severe acute malnutrition (SAM) contributes to nearly 1 million deaths annually worldwide, with diarrhea and pneumonia being the common morbidity associated with mortality.

Objectives: To assess the effect of probiotics on diarrhea, pneumonia, and nutritional recovery in children with uncomplicated SAM.

Methods: A randomized, double-blind, placebo-controlled study was conducted involving 400 children with uncomplicated SAM randomly assigned to ready-to-use therapeutic food (RUTF) either with (n = 200) or without (n = 200) probiotics.

Changes in pupil dilation and P300 amplitude indicate the possible involvement of the locus coeruleus-norepinephrine (LC-NE) system in psychological flow.

Psychological flow is a state of full task immersion. The present study was conducted to test the hypothesis that psychological flow is positively related to activity of the phasic locus coeruleus-norepinephrine (LC-NE) system, which supports decisions on whether to engage in or disengage from the current activity. Subjective flow was assessed among 36 participants who engaged in a gamified version of the n-back task with various difficulty levels (0, 1, 2, and 3 back).

The General Factor of Personality (GFP) is associated with higher salary, having a leadership position, and working in a social job.

Previous studies have suggested that a general factor exists at the top of the hierarchal structure of personality. One interpretation of this General Factor of Personality (GFP) is that it reflects social effectiveness. Accordingly, in a large employee sample (N = 1267), we tested whether the GFP relates to several outcomes assumed to be linked with social effectiveness.

Generalisable machine learning models trained on heart rate variability data to predict mental fatigue.

A prolonged period of cognitive performance often leads to mental fatigue, a psychobiological state that increases the risk of injury and accidents. Previous studies have trained machine learning algorithms on Heart Rate Variability (HRV) data to detect fatigue in order to prevent its consequences. However, the results of these studies cannot be generalised because of various methodological issues including the use of only one type of cognitive task to induce fatigue which makes any predictions task-specific.

SARS-CoV-2 Transmission in Belgian French-Speaking Primary Schools: An Epidemiological Pilot Study.

Schools have been a point of attention during the pandemic, and their closure one of the mitigating measures taken. A better understanding of the dynamics of the transmission of SARS-CoV-2 in elementary education is essential to advise decisionmakers. We conducted an uncontrolled non-interventional prospective study in Belgian French-speaking schools to describe the role of attending asymptomatic children and school staff in the spread of COVID-19 and to estimate the transmission to others.

Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler.

Post-operative bacterial infections are a leading cause of mortality and morbidity after ongoing liver transplantation. Bacteria causing these infections in the hospital setting can exhibit high degrees of resistance to multiple types of antibiotics, which leads to major therapeutic hurdles. Alternate ways of treating these antibiotic-resistant infections are thus urgently needed.

Outbreak of invasive meningococcal disease caused by a meningococcus serogroup B in a nursery school, Wallonia, Belgium, 2018.

Although most invasive meningococcal disease (IMD) cases are sporadic without identified transmission links, outbreaks can occur. We report three cases caused by meningococcus B (MenB) at a Belgian nursery school over 9 months. The first two cases of IMD occurred in spring and summer 2018 in healthy children (aged 3-5 years) attending the same classroom.