Publications by authors named "Dilber Irmak"
Article Synopsis
- Histones are important for gene expression regulation and chromatin structure, but how they are degraded is not well understood, especially in human embryonic stem cells (hESCs).
- In hESCs, the enzyme UBE2K is highly expressed and is essential for controlling histone H3 modification; loss of UBE2K leads to increased repression of genes involved in differentiation due to higher levels of a trimethyltransferase called SETDB1.
- UBE2K not only promotes the breakdown of histone H3 but also influences the levels of repressive H3K9 trimethylation, showing that this mechanism is conserved across species, as seen in worms too.
Article Synopsis
- Pluripotent stem cells, particularly human embryonic stem cells (hESCs) and Huntington's disease-specific induced pluripotent stem cells (HD-iPSCs), are used to investigate the function of the huntingtin protein (HTT) and its role in Huntington's disease.
- The study reveals that HTT interacts with ATF7IP, which regulates the SETDB1 complex, and normally helps to maintain low levels of H3K9 trimethylation (H3K9me3), crucial for gene expression in stem cells.
- In Huntington’s disease, mutant HTT reduces this interaction, leading to increased H3K9me3, impacting gene regulation, particularly those essential for neuronal differentiation, suggesting ATF7
Much information can be obtained from the chemical composition of a fingermark, which can be helpful in crime scene investigation. Immunolabeling can be used to extract information about the donor of the fingermark and it can also act as a fingermark development tool in sequence with the standard fingermark development techniques. However, before immunolabeling can be used in forensic practice more information on the possibilities and limitations of this technique is required.
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