Small Bowel Stricture in a Crohn's Patient: An Unrelated Etiology.

Small bowel strictures are a common complication of Crohn's disease (CD), which can lead to obstruction, perforation, and fistula formation. However, strictures can stem from other etiologies in CD patients, including malignancy, prior surgery, radiation, and ischemia. We present a patient who developed a new long-segment jejunal and ileal stricture within 2 months after ileocolic resection.

Meta-Analysis: Effects of Steatotic Liver Disease-Associated Genetic Risk Alleles on Longitudinal Outcomes.

Background: Genetic variants associated with risk of steatotic liver disease (SLD) may also influence clinical events.

Aims: To perform a systematic review and meta-analysis to determine the impact of SLD-associated genetic variants on hepatic and extrahepatic complications in SLD.

Methods: We searched PubMed, Embase and Medline databases from inception through July 4th, 2024 for studies on adults with SLD that reported effects of PNPLA3, TM6SF2, MBOAT7, HSD17B13 and GCKR variants on the incidence of cirrhosis, major adverse liver outcomes (MALO), cardiovascular disease, extrahepatic malignancy and overall or cause-specific mortality.

Social determinants of health influence the risk of cirrhosis: A diverse nationwide cohort study.

Background And Aims: Cirrhosis is a leading cause of mortality in the United States, with significant disparities influenced by social determinants of health (SDOH). This study evaluated the effects of SDOH on the risk of cirrhosis in a nationwide cohort of patients.

Approach And Results: We conducted a retrospective cross-sectional cohort study from the All of Us Research Program (AOURP), enrolled from 2017 to 2022.

Detection of Barrett's Esophagus Prior to Development of Esophageal and Esophagogastric Junction Adenocarcinoma.

Background & Aims: Guidelines differ on the definition of Barrett's esophagus (BE). We aimed to estimate the detection rate of esophagogastroduodenoscopy (EGD) with biopsy for BE, using longitudinal outcome of adenocarcinoma of the esophagus or esophagogastric junction (EAC, EGJAC) as the gold standard.

Methods: We performed retrospective analyses of US Veterans with EAC/EGJAC between 2017 and 2021 who had an EGD before cancer diagnosis.

Histologic Diagnosis of Pancreatic Cystic Lesions with Endoscopic Ultrasound Fine Needle Biopsy and Impact on Management Decisions.

Purpose: Endoscopic ultrasound with fine needle biopsy (EUS-FNB) has not been well studied in pancreatic cystic lesions (PCLs). This study evaluates the diagnostic performance of EUS-FNB for PCLs and its impact on management decisions.

Methods: We conducted a single-center, retrospective study of patients who had EUS-FNB between March 2016 and February 2024.

Nonalcoholic Fatty Liver Disease in Lean/Nonobese and Obese Individuals: A Comprehensive Review on Prevalence, Pathogenesis, Clinical Outcomes, and Treatment.

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, with an estimated prevalence of 25% globally. NAFLD is closely associated with metabolic syndrome, which are both becoming increasingly more common with increasing rates of insulin resistance, dyslipidemia, and hypertension. Although NAFLD is strongly associated with obesity, lean or nonobese NAFLD is a relatively new phenotype and occurs in patients without increased waist circumference and with or without visceral fat.

Tuberculosis of the middle ear: A systematic review.

Objective: Tuberculous otitis media (TOM) is a rare extrapulmonary manifestation of tuberculosis (TB) and remains challenging to diagnose due to non-specific symptoms. This systematic review identifies clinical characteristics, diagnostic evaluation, and outcomes in cases of TOM.

Methods: A comprehensive literature search utilizing the PubMed, CINAHL, Scopus, and Cochrane Library databases was conducted for relevant articles published between 2000 and 2021.

Characterization of Sensorineural Hearing Loss in Patients With MYH9-Related Disease: A Systematic Review.

Objectives: To review the characteristics and progression of hearing loss in MYH9-related disease (MYH9-RD) patients and present a unique case of bilateral non-simultaneous sudden sensorineural hearing loss (SNHL) in an MYH9-RD patient. MYH9-RD is a rare autosomal dominant platelet disorder. Patients with this disorder have a variable risk of developing SNHL.