-Activation of 2-PySOCFH for Electrophilic Difluoromethylthiolation of Electron-Rich Heteroarenes.

Difluoromethyl 2-pyridyl sulfone (2-PySOCFH) is a readily accessible, cost-effective, and versatile reagent with broad applications in fluoroalkylation and fluoroolefination. Here, we unveil a novel application of 2-PySOCFH in electrophilic difluoromethylthiolation. Key to this advance is the strategic -activation of 2-PySOCFH to generate stable -methylpyridinium salt and pyridine -oxide derivatives.