A Loss-of-Function Variant Causing Primary Autosomal Recessive Hypertrophic Osteoarthropathy.

Primary autosomal recessive hypertrophic osteoarthropathy (PHOAR) type 1 is caused by the failure of the gene product to break down prostaglandins. We report the case of a two-year-old male patient diagnosed with PHOAR1 due to a previously unreported homozygous intragenic deletion. Upon retrospective review of the patient's history, his clinical course proved to be typical of this syndrome, although it had been unrecognized.

Preexisting immunity to the 2009 pandemic H1N1 virus reduces susceptibility to H5N1 infection and disease in ferrets.

Zoonotic infections with emerging influenza viruses occur in the context of population-wide immunity to seasonal strains. Because of the worldwide spread of highly pathogenic clade 2.3.

Impact of Oxygen Stewardship Training on Knowledge and Practice for Oxygen Administration Among Healthcare Professionals Working in the Rajkot District.

Aim: To evaluate the effectiveness of the oxygen stewardship training program in improving knowledge and practices regarding medical oxygen administration among healthcare professionals (HCPs) at the tertiary care teaching hospital.

Methods: A cross-sectional study was conducted among HCPs who participated in the oxygen stewardship training program at P.D.

THRIVE 2.0: A randomized-controlled trial of an obesity prevention intervention designed for infants in pediatric primary care.

Background: Unprecedented rates of overweight and obesity are seen in childhood with evidence suggesting that infancy may be a critical period for the development of this elevated-weight trajectory. The impact of rapid growth in infancy on later obesity may differ by social stratification factors such as race/ethnicity and family income and be mediated by infant feeding and sleeping practices. This paper outlines the protocol for the Teaching Healthy Responsive Parenting during Infancy to promote Vital growth and rEgulation (THRIVE 2.

Quantifying viral pandemic potential from experimental transmission studies.

In the past two decades, two pandemic respiratory viruses (H1N1 and SARS-CoV-2) have emerged via spillover from animal reservoirs. In an effort to avert future pandemics, surveillance studies aimed at identifying zoonotic viruses at high risk of spilling over into humans act to monitor the 'viral chatter' at the animal-human interface. These studies are hampered, however, by the diversity of zoonotic viruses and the limited tools available to assess pandemic risk.

Adult-Onset Still's Disease (AOSD) in Patient with Previous Lyme Disease.

Adult-onset Still's Disease (AOSD) is a rare autoimmune disorder causing systemic inflammation that presents with a rash, fever, polyarthritis, and a characteristic serum hyperferritinemia. There is a complex relationship between infections and autoimmune disease, however, the association of AOSD with lyme disease is not well established. Here we present a case of AOSD in a 29-year-old male with a recent history of lyme disease.

Ileocecectomy as an Acceptable Alternative to Right Hemicolectomy in Trauma: A Propensity Score Matched TQIP Analysis.

BackgroundIleocecectomy (IC) as an alternative to right hemicolectomy (RH) for traumatic indication is controversial with limited comparison data. We sought to compare IC vs RH for traumatic injury and hypothesized there was no difference in outcomes.MethodsThe Trauma Quality Improvement Program database was queried from 2017 to 2022 with IC and RH patients evaluated using propensity score matching (PSM) in a 1:3 ratio.

Combined Open Rhinoplasty and Vertical Incision Approach to Addressing a Recurrent Nasal Dermoid Sinus: A Case Report.

A three-year-old boy was referred to our clinic for a draining lesion on the dorsum of the nose, several months following the surgical excision of a nasal dermoid cyst in Egypt. Physical examination demonstrated a pit on the skin of the nasal dorsum, and magnetic resonance imaging (MRI) was consistent with dermoid cyst recurrence. The patient underwent reoperation using a combined vertical incision and open rhinoplasty approach, with excellent pathologic and cosmetic results.

The Acute Management of Penetrating Carotid Artery Injuries: A Systematic Review.

Background: Penetrating carotid artery injuries (CAIs) are rare with high morbidity and mortality. We aimed to perform a systematic review of the published literature to evaluate the work-up and management of penetrating CAI.

Methods: Studies of acute management of adult trauma patients with penetrating common or internal CAIs on MEDLINE or EMBASE from 1946 through July 2024 were included following the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement methodology.

Germline CDH1 Variants and Lifetime Cancer Risk.

Importance: Approximately 1% to 3% of gastric cancers and 5% of lobular breast cancers are hereditary. Loss of function CDH1 gene variants are the most common gene variants associated with hereditary diffuse gastric cancer and lobular breast cancer. Previously, the lifetime risk of gastric cancer was estimated to be approximately 25% to 83% and for breast cancer it was estimated to be approximately 39% to 55% in individuals with loss of function CDH1 gene variants.

Risk assessment of a highly pathogenic H5N1 influenza virus from mink.

Outbreaks of highly pathogenic H5N1 clade 2.3.4.

Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model.

Multiple vaccines have been developed and licensed for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). While these vaccines reduce disease severity, they do not prevent infection. To prevent infection and limit transmission, vaccines must be developed that induce immunity in the respiratory tract.

Development of an Electronic Decision Aid Tool to Facilitate Mainstream Genetic Testing in Ovarian Cancer Patients.

Background: Multigene panel testing is an important component of cancer treatment plans and risk assessment, but there are many different panel options and choosing the most appropriate panel can be challenging for health care providers and patients. Electronic tools have been proposed to help patients make informed decisions about which gene panel to choose by considering their preferences and priorities.

Materials And Methods: An electronic decision aid (DA) tool was developed in line with the International Patient Decision Aids Standards collaboration.

Timing to Rib Fixation in Patients With Flail Chest.

Introduction: Flail chest (FC) after blunt trauma is associated with significant morbidity and prolonged hospitalizations. The goal of this study was to examine the relationship between timing of rib fixation (ORIF) and pulmonary morbidity and mortality in patients with FC.

Methods: FC patients were identified from the Trauma Quality Improvement Program database over 3-year, ending 2019.

Segmental Duodenal Resections: Toward Defining Indications, Complexity, and Coding.

Background: Segmental resections of the duodenum are uncommonly performed and are technically challenging due to intimate relationships with the biliary tree, pancreas, and superior mesenteric vessels. The objective of this study was to assess indications, operative strategy, and outcomes of duodenal resections and to advocate that this form of resection deserves its own unique Current Procedural Terminology (CPT) and Relative Value Unit (RVU) structure.

Methods: Patients undergoing isolated and partial duodenal resection from 2008-2023 at University of Tennessee Health Science Center affiliated hospitals were retrospectively reviewed.

The Family Biorhythm: Contributions of the HPA and HPG Axes to Neuroendocrine Attunement.

Objective: The vast majority of research on biobehavioral influences on development has focused on mothers and infants, whereas research on paternal biobehavioral influences remains sparse. This study aims to increase understanding of paternal influences on the biobehavioral dynamics of the family unit, using a multi-system approach.

Methods: Participants consisted of 32 predominantly high-risk families recruited during pregnancy who completed monthly questionnaires and in-home visits when infants were 4, 12, and 18 months of age.

Role of Endovascular Stenting in Patients with Traumatic Iliac Artery Injury.

Background: Common and external iliac artery injuries (IAI) portend significant morbidity and mortality. The goal of this study was to examine the impact of mechanism of injury and type of repair on outcomes and identify the optimal repair for patients with traumatic IAI using a large, national dataset.

Study Design: Patients undergoing operative repair for IAI were identified from the Trauma Quality Improvement Program database during a 5-year timespan, ending in 2019.

Parents of Children With High Weight Are Viewed as Responsible for Child Weight and Thus Stigmatized.

Courts in seven U.S. states have removed children with "obesity" from parental custody until children could maintain "healthy weights.

Sequential Transmission of Influenza Viruses in Ferrets Does Not Enhance Infectivity and Does Not Predict Transmissibility in Humans.

Airborne transmission in ferrets is a key component of pandemic risk assessment. However, some emerging avian influenza viruses transmit between ferrets but do not spread in humans. Therefore, we evaluated sequential rounds of airborne transmission as an approach to enhance the predictive accuracy of the ferret model.

Aerosolized Hydrogen Peroxide Decontamination of N95 Respirators, with Fit-Testing and Viral Inactivation, Demonstrates Feasibility for Reuse during the COVID-19 Pandemic.

In response to the demand for N95 respirators by health care workers during the COVID-19 pandemic, we evaluated decontamination of N95 respirators using an aerosolized hydrogen peroxide (aHP) system. This system is designed to dispense a consistent atomized spray of aerosolized, 7% hydrogen peroxide (HO) solution over a treatment cycle. Multiple N95 respirator models were subjected to 10 or more cycles of respirator decontamination, with a select number periodically assessed for qualitative and quantitative fit testing.

Vitamin D and the Ability to Produce 1,25(OH)D Are Critical for Protection from Viral Infection of the Lungs.

Vitamin D supplementation is linked to improved outcomes from respiratory virus infection, and the COVID-19 pandemic renewed interest in understanding the potential role of vitamin D in protecting the lung from viral infections. Therefore, we evaluated the role of vitamin D using animal models of pandemic H1N1 influenza and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. In mice, dietary-induced vitamin D deficiency resulted in lung inflammation that was present prior to infection.

Pathogenomic in silico approach identifies NSP-A and Fe-IIISBP as possible drug targets in Neisseria Meningitidis MC58 and development of pharmacophores as novel therapeutic candidates.

Meningitis creates a life-threatening clinical crisis. Moreover, the administered antibiotics result into multi-drug resistance, thereby necessitating development of alternative therapeutic strategies. This study aimed at identifying novel-drug targets in Neisseria meningitidis and therapeutic molecules which can be exploited for the treatment of meningitis.

Microdosimetric and radiobiological effects of gold nanoparticles at therapeutic radiation energies.

Purpose: The purpose of this study was to quantify the microscopic dose distribution surrounding gold nanoparticles (GNPs) irradiated at therapeutic energies and to measure the changes in cell survival in vitro caused by this dose enhancement.

Methods: The dose distributions from secondary electrons surrounding a single gold nanosphere and single gold nanocube of equal volume were both simulated using MCNP6. Dose enhancement factors (DEFs) in the 1 μm volume surrounding a GNP were calculated and compared between a nanosphere and nanocube and between 6 and 18 MV energies.