Publications by authors named "Devan C Diwanji"
Article Synopsis
- Furin cleavage of HIV envelope proteins is crucial for allowing the virus to enter cells by forming stable, well-structured trimers and protecting against enzymatic breakdown.
- A stable, cleavage-independent Env trimer mimic, named BG505 NFL.664, retains a native-like structure similar to furin-cleaved forms, making it a valuable model for study.
- Analysis of BG505 NFL.664 reveals it has intact glycan shielding and maintains essential protein structures, highlighting its potential use as a candidate for developing effective vaccines against HIV.
New broad and potent neutralizing HIV-1 antibodies have recently been described that are largely dependent on the gp120 N332 glycan for Env recognition. Members of the PGT121 family of antibodies, isolated from an African donor, neutralize ∼70% of circulating isolates with a median IC50 less than 0.05 µg ml(-1).
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