Publications by authors named "Dereje Shegu"

Peste des Petits Ruminants is a contagious trans-boundary viral disease affecting domestic and wild small ruminants, causing high mortality and morbidity. A cross-sectional study was conducted from January to December 2024 in the Enderta and Kilteawulaelo districts of the Tigray region, Ethiopia. The study aimed to assess the seroprevalence, associated risk factors, and investigate the recent circulation of the Peste des Petits Ruminants virus strains in small ruminants.

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Article Synopsis
  • Peste des Petits Ruminants (PPR) is a viral disease affecting primarily goats and sheep, with some controversy around its impact on atypical hosts like cattle, warranting investigation into its progression in both species.
  • The study involved 32 animals (16 goats and 16 cattle) inoculated with a specific PPR virus strain, leading to significant clinical differences: goats showed typical symptoms and earlier virus detection than cattle, which displayed milder signs.
  • Findings emphasize the need for further comparative pathology studies to enhance understanding of PPR virus dynamics and potential transmission pathways, which could be crucial for controlling outbreaks.
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  • Peste des petits ruminants virus (PPRV) primarily affects sheep and goats, but this study examined the potential role of cattle in spreading the virus.
  • Despite co-housing Zebu cattle with goats and infecting the cattle with PPRV, there was no transmission to the goats, confirming that cattle have a minimal role in PPRV spread.
  • The study supports the idea that vaccinating small ruminants is enough for eradication, but warns that more virulent PPRV strains could emerge in cattle, highlighting the need for ongoing monitoring.
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The lumpy skin disease (LSD) vaccination status and epidemiological distribution remain unknown in some parts of Ethiopia, including the Sidama regional state. In this study, a serological survey of LSD was performed using a specific virus neutralization assay in selected districts of the Sidama regional state representing three agroecological zones from September 2021 to June 2022. Moreover, an assessment of community awareness and LSD vaccine-related problems was conducted using a questionnaire.

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Wastewater surveillance systems have become an important component of COVID-19 outbreak monitoring in high-income settings. However, its use in most low-income settings has not been well-studied. This study assessed the feasibility and utility of wastewater surveillance system to monitor SARS-CoV-2 RNA in Addis Ababa, Ethiopia.

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Routine meat inspection in the abattoir was used to examine carcass for subsequent approval for consumption. However, the chance of missing lesions results in approval of carcass and/or the offal with lesions of tuberculosis. A cross-sectional study was conducted at Debre Birhan Municipal abattoir from October 2016 to May 2017.

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  • *The study, conducted from March 2016 to May 2017, involved testing 5,675 cattle across 299 dairy herds, resulting in an estimated herd-level prevalence of 54.4% and an individual animal prevalence of 24.5%.
  • *Risk factors identified for bTB positivity included herd size, age, previous bTB history, and breed, with larger herds facing significantly increased odds of infection, particularly in older animals.
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One of the constraints to controlling foot-and-mouth disease (FMD) in East Africa is the incomplete knowledge of the specific FMD virus (FMDV) strains circulating and the way in which these viruses move across countries in the region. This retrospective study focuses on Ethiopia, which has one of the largest FMD-susceptible livestock populations in Africa. Analyses of FMDV positive samples collected between 2008 and 2019 demonstrate that serotypes O (n = 175), A (n = 51) and SAT 2 (n = 33) were present in the country.

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Sequencing of the VP2 region was carried out to identify amino acid mismatches between vaccine strains and field isolates of infectious bursal disease virus (IBDV). Viruses were isolated in chicken embryo fibroblast (DF-1) cells using pooled samples of bursa collected from nine outbreaks, which affected 30,250 chickens in five localities, with an overall mortality of 47.87%.

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Lumpy skin disease (LSD) is an acute or inapparent viral disease of cattle which is endemic in many African and Middle East countries. LSD is one of the major transboundary livestock diseases in Ethiopia. A cross-sectional study using multistage cluster sampling was undertaken in central and north-western parts of Ethiopia with the objectives to estimate seroprevalence and to identify and quantify risk factors contributing to the occurrence of the disease.

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Background: Ethiopian livestock production and productivity is still very low due to widespread of diseases. Among the diseases, foot-and-mouth disease (FMD) is an extremely contagious and acute viral disease that causes significant economic problems in the country. A cross sectional study design was conducted from September 2015 to May 2016 to isolate and characterize FMD virus from outbreak cases; determine the sero-prevalence of antibodies against FMD virus (FMDV), and assess potential risk factors associated with sero-prevalence of the disease in selected areas of central Ethiopia.

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