Publications by authors named "Denise Pinheiro Falcao"

Objective: To evaluate the effect of chemically modified tetracycline-3 (CMT-3) and simvastatin on tooth relapse after orthodontic movement in rats using a novel analysis method employing high-resolution micro-CT (Micro-CT) images. In addition, the correlation between bone density and orthodontic relapse was also evaluated for each experimental group.

Methods: Forty adult male Wistar rats had stainless steel springs installed on their left upper first molars in order to generate tooth movement for 18 days.

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Article Synopsis
  • The study investigates the risk of malignant transformation in oral lichen planus (OLP) by analyzing the expression levels of potential precancerous biomarkers: p16, Ki-67, Bub-3, and SOX4.
  • Significant differences were found in p16 and Ki-67 positivity indices among OLP, oral dysplasia, and other conditions, indicating varying levels of malignancy risk.
  • The findings point to the need for monitoring specific OLP lesions due to their intermediate malignant potential, especially highlighting the different behavior of SOX4 in oral dysplasia compared to OLP.
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Unlabelled: Halitosis is defined as a foul odor emanated from the oral cavity, with great impact in quality of life and social restraints. Recently, the use of Breath Alert™ in research increased significantly. Halimeter™, another portable device, is often used in clinical practice.

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Hypnosis is a valuable tool in the management of patients who undergo surgical procedures in the maxillofacial complex, particularly in reducing and eliminating pain during surgery and aiding patients who have dental fear and are allergic to anesthesia. This case report demonstrates the efficacy of hypnosis in mitigating anxiety, bleeding, and pain during dental surgery without anesthesia during implant placement of tooth 14, the upper left first molar.

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Objectives: The purpose of this study was to evaluate the effect of type 2 diabetes mellitus (T2DM) on salivary function impairments according to glycemic control status and subsequently compare the concentration of chromogranin A (CHGA) with its genetic profile.

Materials And Methods: Thirty-six patients with controlled T2DM, 36 with poorly controlled T2DM, and 38 nondiabetic subjects underwent salivary flow rate measurements by means of unstimulated labial (ULS), unstimulated whole (UWS), and stimulated whole saliva (SWS) collections. CHGA concentrations were determined in saliva and plasma with ELISA, and two CHGA polymorphisms (T-415C and Glu264Asp) were analyzed by polymerase chain reaction-restriction fragment length polymorphism.

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Article Synopsis
  • Orofacial manifestations are common early signs of rheumatic diseases but are often overlooked in clinical settings.
  • Autoimmune rheumatic diseases like rheumatoid arthritis, systemic lupus erythematosus, and Sjögren's syndrome can show symptoms such as dry mouth, joint disorders, and mouth lesions.
  • The article highlights the importance of recognizing these orofacial symptoms for rheumatologists in diagnosing and tracking these diseases.
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Systemic lupus erythematosus (SLE) is a chronic multisystemic disease characterized by autoimmune inflammatory disturbance. Pleomorphic manifestations are present and a potentially progressive and debilitating course can be detected. SLE rarely manifests before age 5, and its onset peaks is around puberty.

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Article Synopsis
  • - Orofacial manifestations are common indicators of rheumatic diseases and often show up early, but they're frequently overlooked in medical practice.
  • - Autoimmune conditions like rheumatoid arthritis, systemic lupus erythematosus, and Sjögren's syndrome can show symptoms such as dry mouth, joint issues, and oral lesions.
  • - The article highlights the importance of recognizing these orofacial signs in contributing to the diagnosis and management of autoimmune rheumatic diseases for healthcare professionals.
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Objective: To evaluate the effect of glycemic control status in type 2 diabetes mellitus (T2DM) individuals on clinical oral health indicators and to compare the concentrations of plasma and salivary chromogranin A (CHGA) among nondiabetic subjects and T2DM patients, exploring their associations.

Design: In this cross-sectional study, 32 patients with controlled T2DM, 31 with poorly controlled T2DM and 37 nondiabetic subjects underwent a clinical and periodontal examination. CHGA concentrations were determined in saliva and plasma with ELISA.

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Objectives: To establish referential values ranges of hyposalivation and normosalivation for the salivary flow rate (SFR) of upper labial (LS) and palatal (PS) mucosa using Schirmer's test strips paper and as a second goal to determine the values ranges of the SFR of palatal (PS) and upper labial (LS) mucosa in subjects with and without xerostomia.

Methods: A cross-sectional study was conducted among subjects distributed in three groups according to their unstimulated and stimulated whole saliva.

Results: 144 subjects were enrolled in groups as follows: severe hyposalivation (n = 24), mild hyposalivation (n = 78), and normosalivation (n = 42).

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Purpose: To compare salivary and serum cortisol levels, salivary alpha-amylase (sAA), and unstimulated whole saliva (UWS) flow rate in pregnant and non-pregnant women.

Method: A longitudinal study was conducted at a health promotion center of a university hospital. Nine pregnant and 12 non-pregnant women participated in the study.

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Whole saliva is a multiglandular secretion complex consisting of gingival fluid, desquamated epithelial cells, microorganisms, products of bacterial metabolism, food debris, leukocytes mucus from the nasal cavity and the pharynx. Saliva has many functions, including tissue repair, tamponage, protection, digestion, taste, antimicrobial action, maintaining tooth integrity and antioxidant defense system. A decrease in salivary flow (hyposalivation) is a common disorder and it is estimated that approximately 20% of the general population have this alteration.

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It is known that almost one-third of patients who seeks treatment for bad breath do not have genuine halitosis. Halitosis can occur even in cases when the malodor is not perceived by those around the patient and can neither be confirmed by organoleptic tests, nor by sulfur portable monitor readings. In such cases, these patients have been considered as halitophobic or have pseudo-halitosis.

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