Publications by authors named "Delfina Petrone"
Aims: Obstructive sleep apnea (OSA) affects up to 40% of children and adolescents with obesity and is linked to hyperinsulinism. However, the mechanisms underpinning this association remain unclear. The study aims to assess the three key determinants of hyperinsulinemia: insulin clearance, secretion, and sensitivity in paediatric patients with OSA.
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- Acute kidney injury (AKI) in children is often overlooked and poses significant challenges in pediatric healthcare, with various causes including renal damage and inflammation.
- Diagnosis typically uses traditional markers like serum creatinine, as well as new biomarkers such as Cystatin C and NGAL, which help identify AKI more effectively.
- Treatment focuses on supportive care and fluid management, with severe cases potentially requiring renal replacement therapy; raising awareness and incorporating new diagnostic tools could enhance outcomes for affected children.
Unlabelled: The role of obesity as risk factor for chronic kidney disease (CKD) has been well-recognized. As previously demonstrated in adults, emerging data highlighted the relevant impact of obesity on renal function since childhood. As a matter of fact, obesity also affects renal health through a complex pathogenic mechanism in which insulin resistance (IR) plays a pivotal role.
View Article and Find Full Text PDFBackground: We evaluated the diagnostic performance of height-, age- and body surface area (BSA)-based kidney length (KL) percentiles in the identification of at least one small kidney (KL < 3) and in the prediction of reduced estimated glomerular filtration rate (eGFR) and/or elevated blood pressure (BP) in children with and without overweight (OW)/obesity(OB).
Methods: In this cross-sectional study, 744 apparently healthy children (mean age 8.3 years) were recruited in a primary care setting.