Conservative Management Versus Early Cholecystectomy for Gallstone Disease: A Meta-Analysis of Randomized Controlled Trials.

Objective: While most individuals with gallstone disease remain asymptomatic, symptoms of gallstone disease range from biliary pain to acute cholecystitis. Surgery is a popular choice of treatment, but evidence has also suggested conservative management as a safe and viable approach. We aim to investigate the evidence on conservative management versus early cholecystectomy for the management of gallstone disease.

The Great Mimicker: Pancreatic Tuberculosis Masquerading as a Pancreatic Neoplasm.

Pancreatic tuberculosis is a rare manifestation of extrapulmonary tuberculosis, often mimicking pancreatic cancer clinically and radiologically. We report a 26-year-old immunocompetent farmer from a tuberculosis-endemic area presenting with a two-month history of fever, night sweats, and significant weight loss. Although malignancy was suspected, contrast-enhanced computed tomography of the abdomen showed a complex lesion in the pancreatic body with central necrosis and an enlarged lymph node.

Evolving Horizons in Pediatric Leukemia: Novel Insights, Challenges, and the Journey Ahead.

Pediatric leukemia, encompassing acute lymphoblastic leukemia (ALL) and acute myeloid leukemia, remains a formidable challenge despite significant treatment advancements. This review examines recent developments in immunotherapy, chemotherapy, and bone marrow transplantation for pediatric leukemia through a comprehensive analysis of recent literature, focusing on critical studies and clinical trials. Immunotherapy, including monoclonal antibodies, such as blinatumomab and inotuzumab ozogamicin, and chimeric antigen receptor T-cell therapies, such as tisagenlecleucel and brexucabtagene autoleucel, have demonstrated promising results in relapsed or refractory B-cell ALL (B-ALL), achieving notable remission rates with manageable side effects.