Publications by authors named "Deepak Vallabhaneni"
We describe the synthesis of Xyzidepsin, a depsipeptidic analogue of HDAC inhibitor Romidepsin (FK228), using a solid-phase strategy. Our latent thioester solid-phase linker was synthesized in 92% yield (three steps). Chemoselective conditions unmasked the thioester functionality and cyclized the depsipeptidic macrocycle.
View Article and Find Full Text PDFWe present a case of acute and chronic ischemia in the bilateral cerebellar border zones in a patient with migraine with aura. To our knowledge, this imaging presentation has not been published. The patient presented with 20 years of migraines that had worsened with developing aura prior to MRI, which showed restricted diffusion in the bilateral cerebellar border zones, consistent with acute ischemia.
View Article and Find Full Text PDFArticle Synopsis
- Encephalitis involves inflammation of the brain and can have infectious and noninfectious origins, with specific diagnostic tools like CSF analysis and MRI typically showing inflammatory changes.
- A case study presented a 65-year-old woman with a fall and confusion, where initial tests for infections were negative, but brain imaging showed abnormal findings, complicating the diagnosis.
- Ultimately, after treatment failures, she tested positive for GAD65 antibodies, indicating autoimmune encephalitis, and her symptoms drastically improved with plasmapheresis, marking a unique case due to its unusual imaging characteristics.
Enhancing Mass Lesion of the Sphenoid: Atypical Presentation of Ongoing Pneumatization.
Case Rep Pediatr
December 2016
Article Synopsis
- Sinus pneumatization is a gradual process that continues throughout childhood, which can sometimes lead to complications during diagnosis.
- A case is presented of a 6-year-old boy experiencing headaches and neurological symptoms, leading to concerns about potential brain issues due to abnormal tissue in the sphenoid sinus.
- Understanding the imaging signs of incomplete pneumatization is crucial for distinguishing it from serious skull base conditions, which can help avoid unnecessary medical interventions.