Impact of a comprehensive sickle cell disease care programme on community knowledge among Indian tribal populations: a multicentric study.

Background: India has initiated a programme to eliminate sickle cell disease (SCD) by 2047. As the programme progresses with screening, treatment, management and preventive activities will eventually be initiated. However, the community's knowledge and involvement are important for effective implementation of these public health interventions.

Indian Council of Medical Research (ICMR)-Sickle cell disease (SCD) Stigma Scale for India (ISSSI): development and psychometrics.

Background: Sickle Cell Disease (SCD) places a significant psychological and social burden on patients and their caregivers, often leading to stigma that further diminishes their quality of life. Despite the huge burden of SCD and associated stigma in India, not much research has been done, and no stigma measurement tool is available. Hence, the Indian Council of Medical Research (ICMR) has undertaken a multi-centric study to develop the ICMR-SCD Stigma Scale for India (ISSSI).

Transcranial Doppler Screening in Sickle Cell Disease: Insights from a Regional Study in Karnataka, India.

Sickle cell disease (SCD), a hereditary blood disorder in India, disproportionately affects Adivasi communities burdened by socio-economic and systemic inequities. Stroke, a severe complication of SCD, is underexplored in Indian populations, especially among Adivasi groups. This pilot study evaluated the feasibility of transcranial Doppler (TCD) screening in a peripheral healthcare setting in Karnataka, focusing on Adivasi SCD patients.

Socioeconomic health and impact of sickle cell disease and vaso-occlusive crises in India: results from B-VOCAL study.

Background: Sickle cell disease (SCD) with vaso-occlusive pain crisis (VOC) has a major impact on healthcare resource utilisation and poses a significant financial burden for the patients. This study examines the economic implications of managing VOC in individuals with SCD in India, from the perspectives of patients, healthcare system and society.

Methods: This cross-sectional, observational study included 1000 patients with SCD across 14 centres enrolled from November 2021 to June 2022.

Primary healthcare utilization patterns among sickle cell disease patients in tribal India: A multi-centric study.

Background: Prevention and management of chronic diseases have been integrated into the primary healthcare system in recent years. However, due to the social, cultural and geographical barriers, patients of one of such chronic illnesses, viz., sickle cell disease (SCD) have poor utilization and access to healthcare services.

Access to Healthcare Among Tribal Population in India: A Cross-Sectional Household Survey.

This study addresses significant healthcare access challenges faced by India's 104 million-strong tribal population, who are among the most disadvantaged and typically live in hilly rural and remote areas with poor health infrastructure and resources. The study aims to examine healthcare access patterns in six tribal areas, focussing on primary health centres (PHCs), to develop a strategy that improves healthcare service accessibility, quality, and utilization for tribal communities. Data were collected from 9837 participants from 24 PHC areas across six states.

Navigating health policies and programs in India: exploring opportunities to improve rare disease management and orphan drug research.

Background: Rare disease (RD) management and orphan drug development in India face various hurdles regarding the implementation and adoption of comprehensive policies, lack of dedicated regulatory frameworks, and absence of epidemiological data. Current rare disease policy focuses more on strengthening the diagnostics and lacks a proper comprehensive treatment framework to ensure favorable clinical outcomes. Indian patients are largely excluded from global orphan drug clinical trials.

Comparing Different Pathways in Medical Education and Surgical Training: A Global Survey of Surgeons.

Background: Currently, interest in surgical careers is declining globally, whereas aging populations are contributing to a rising demand for surgical procedures. Surgeons who conduct scientific investigations and share clinical advances internationally pay little attention to comparing differences in ways nations attract, educate, and train their surgeons. This study compares international pathways toward surgeon development with the aim of seeking best practices and improving the outlook of surgery as an attractive career.

Burden of vaso-occlusive crisis, its management and impact on quality of life of Indian sickle cell disease patients.

Sickle cell disease (SCD) with vaso-occlusive pain crisis (VOC) significantly impacts patient well-being and often results in extensive healthcare resource utilization. This study assessed the VOC burden, its management and its impact on patients' quality of life (QoL). A cross-sectional observational study was conducted between November 2021 and June 2022, including 1000 SCD patients from high-prevalence states in India.

Sickle cell disease in Indian tribal population: Findings of a multi-centre Indian SCD registry.

Background: Sickle cell disease (SCD) registries provide crucial real-world data on demographics, epidemiology, healthcare, patient outcomes, and treatment efficacy. This paper presents findings from the Indian SCD Registry (ISCDR) on clinical manifestations, crisis episodes, disease management, and healthcare utilization in patients with SCD from 12 primary health centres (PHCs) in six tribal districts of India.

Methods: The ISCDR was introduced along with a three-tier screening process.

Labial Length and Patient Symptomatology: Is There a Correlation?

Background: Labia minora length is used in classification systems and to determine labiaplasty candidacy, with shorter labia leading to nonsurgical recommendations.

Objectives: The aim of the study was to investigate the correlation between labia length and symptomatology.

Methods: Patients undergoing labiaplasty from January 2017 to May 2023 underwent chart review.

Strengthening Health System and Community Mobilization for Sickle Cell Disease Screening and Management among Tribal Populations in India: An Interventional Study.

Sickle cell disease (SCD) affects 5% of the global population, with over 300,000 infants born yearly. In India, 73% of those with the sickle hemoglobin gene belong to indigenous tribes in remote regions lacking proper healthcare. Despite the prevalence of SCD, India lacked state-led public health programs until recently, leaving a gap in screening and comprehensive care.

Stigma of sickle cell disease among Indian tribal population: A multi-centric qualitative study.

Background: Sickle Cell Disease (SCD) is the most prevalent hemoglobinopathy, impacting around 5% of the global population. The Indian tribal population, which has been a key focus of the Indian SCD program, can experience health-related stigma due to the multidimensional impact of the disease. This preliminary qualitative inquiry delves into the lived experiences of individuals and synthesizes domains to identify the sources of stigma.

Response to correspondence article on the research protocol titled .

In this correspondence, we, co-authors and collaborators involved in the  respond to a recent article published in Wellcome Open Research titled  In the first part, we provide overall clarifications on the THETA study and in the second part respond to specific comments by the authors of the aforementioned correspondence.

Genetic counseling in sickle cell disease: Insights from the Indian tribal population.

Sickle cell disease (SCD) is an inherited disorder of hemoglobin. With an overall prevalence of 4.3%, India is the second-largest hub of SCD after Africa.

Indian sickle cell disease registry for surveillance and patient management: Development and implementation.

In India, sickle cell disease (SCD) predominantly occurs in indigenous (tribal) people, who are about 104 million. However, screening and diagnosis seldom happen. This situation necessitates developing a comprehensive SCD care model, including a registry.

Defining the Ideal Male Buttocks.

Background: There is no well-defined male buttock aesthetic. The authors performed a crowdsourced analysis to define the ideal male buttocks.

Methods: A survey was deployed using the Amazon MTurk platform.

Algorithm for Trim and Wedge Labiaplasties.

In the last decade labiaplasty procedures have been on the rise in the United States. The trim and the wedge are among the most commonly used techniques. The purpose of this paper is to provide a trim-wedge algorithm to guide the surgeon based on the qualities of the individual patient.

It is just not short stature.

Russell-Silver syndrome, also called asymmetric dwarf dysgenesis syndrome is an uncommon genetic disorder presenting with low birth weight, failure to thrive and growth retardation (short stature), developmental delay, facial dysmorphism and hemihypertrophy. The estimated incidence is between 1 case in 3,000 to 1 case in 100,000. We are hereby reporting one such case of postnatal growth retardation with facial dysmorphism and several other features of Russell-Silver syndrome and confirmed by genetic analysis.

Sickle cell disease-related knowledge and perceptions of traditional healers in tribal communities in India: implications on sickle cell disease programme.

Sickle cell disease (SCD) is a progressively debilitating genetic disease, and India is the second most affected nation in the prevalence of births with SCD. This SCD prevalence is high among Indian indigenous tribal communities, whose healthcare is pluralistic. Traditional healers are an essential part of tribal pluralistic care.

Feasibility of population-based screening of sickle cell disease through the primary health care system in tribal areas of India.

Objective: To describe the development and implementation of a population-based screening programme for sickle cell disease (SCD) implemented in 12 SCD-endemic and tribal-dominated primary/community health centres (PHCs/CHCs) across six districts of India.

Setting: India reports a huge burden of SCD, especially among indigenous (tribal) communities. However, there is no state-led SCD programme in many places, and systematic screening is absent.

Evaluation of Remineralizing Potential of CPP-ACP, CPP-ACP + F and β TCP + F and Their Effect on Microhardness of Enamel Using Vickers Microhardness Test: An Study.

Context: The change in understanding of dental caries which is now believed to be a reversible lesion has led to the change in its management.

Aim: To evaluate the remineralizing potential of three remineralizing agents [casein phosphopeptide (CPP)-amorphous calcium phosphate (ACP), CPP-ACP + F, and beta-tricalcium phosphate (β TCP) + F] and their effect on microhardness of enamel using Vickers microhardness test.

Materials And Method: Forty freshly extracted premolars, extracted for orthodontic purpose were collected and specimen prepared.