Publications by authors named "Debora D'Elia"
Article Synopsis
- This study examines the impact of starting PCSK9 inhibitors (PCSK9i) at the time of hospitalization for acute coronary syndrome (ACS) on lipid levels and cardiovascular (CV) events in a real-world setting.
- It analyzed data from 771 ACS patients, revealing that a significant 68.3% achieved the target LDL-C of < 55 mg/dL within a median of 37 days after hospitalization.
- Results showed that lower LDL-C levels were associated with reduced risks of major cardiovascular events, suggesting that early and aggressive lipid management with PCSK9i is both safe and beneficial for ACS patients.
Article Synopsis
- Over the past few decades, bioprosthetic heart valves have become more common than mechanical valves in surgical aortic valve replacements, but structural valve deterioration is a frequent issue that may require further intervention.
- * The innovation of valve-in-valve transcatheter aortic valve replacement (ViV TAVR) has emerged as a practical solution for patients with failed bioprosthetic valves, especially those at high surgical risk.
- * This review highlights the importance of multidisciplinary planning, current clinical evidence, procedural techniques, and potential complications to optimize ViV TAVR outcomes for both surgical and transcatheter heart valve failures.
Article Synopsis
- * Lipoprotein(a) (Lp(a)) has been identified as a key factor predicting adverse outcomes after ACS, leading to the development of new therapies that can lower Lp(a) levels and improve long-term outcomes.
- * Recent research highlights the roles of inflammation, gut microbiome, and novel targets in secondary prevention strategies, suggesting a need for personalized approaches in managing high-risk patients post-ACS.
Acute coronary syndromes (ACS) may complicate the clinical course of patients with Coronavirus Disease 2019 (COVID-19). It is still unclear whether this condition is a direct consequence of the primary disease. However, several mechanisms including direct cellular damage, endothelial dysfunction, in-situ thrombosis, systemic inflammatory response, and oxygen supply-demand imbalance have been described in patients with COVID-19.
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