Soluble Oncoimmunome Signatures Predict Muscle Mass Response to Enriched Immunonutrition in Cancer Patients: Subanalysis of a Multicenter Randomized Clinical Trial.

Background/objectives: Enriched oral nutritional supplementation (ONS) has been shown to increase muscle mass in cancer patients. This study aims to identify the immunomodulatory effects and predictive biomarkers associated with this intervention.

Methods: The soluble levels of 92 immune- and oncology-related mediators were determined before and after an intervention (8 weeks) in 28 patients with cancer receiving either a standard (n = 14) or an enriched ONS (n = 14) using the Olink proteomics analysis pipeline (Olink Target 96 Immuno-Oncology panel (Uppsala, Sweden)) Results: Patients receiving enriched ONS experienced an average weight gain of 1.

Fibroblast growth factor 21 as marker of low protein intake in patients with disease-related malnutrition.

Introduction: FGF21 has potential functions as a key regulator in coordinating the metabolic response to protein deficiency.

Objective: the aim of our design is to explore the role of circulating FGF21 in patients with disease-related-malnutrition (DRM) and its relationship with protein dietary intake.

Material And Methods: 108 DRM patients were included.

Effect of an oral inmunoenhanced formula on sarcopenia and quality of life in ambulatory patients with cancer.

Background: patients with cancer are a group of high risk of malnutrition and sarcopenia. Inmunoenhanced oral nutritional supplements (ONS) can improve this complex situation. Objective: the objective of our study was to assess the effectiveness of an inmunoenhanced oral nutritional supplements (ONS) on sarcopenia and quality of life (QoL) in ambulatory patients with cancer and malnutrition.

[Albumin-myoestatosis gauge assisted by an artificial intelligence tool as a prognostic factor in patients with metastatic colorectal-cancer].

Objectives: to evaluate the prognostic role of the marker albumin-myosteatosis (MAM) in Caucasian patients with metastatic colorectal cancer.

Material And Methods: this study involved 55 consecutive Caucasian patients diagnosed with metastatic colorectal cancer. CT scans at the L3 vertebral level were analyzed to determine skeletal muscle cross-sectional area, skeletal muscle index (SMI), and skeletal muscle density (SMD).

Brain-Derived Neurotrophic Factor Is Related with Sarcopenia in Patients with Disease-Related Malnutrition.

Introduction: Sarcopenia is a condition characterized by muscle mass loss. Some investigations have demonstrated the role of brain-derived neurotrophic factor (BDNF) as a protector against the presence of sarcopenia in patients with chronic kidney disease. We aimed to explore the role of circulating BDNF in the development of sarcopenia among individuals with disease-related malnutrition (DRM).

Role of rs490683 variant in the promoter region of the ghrelin receptor gene on body weight and metabolic syndrome after a partial meal replacement hypocaloric diet.

Background And Aims: Few studies have evaluated the effect of rs490683 on weight loss. The objective of our study was to evaluate the role of this variant of GHSR gene on body weight loss and cardiovascular risk factors secondary to a partial meal replacement (pMR) hypocaloric diet.

Methods: 96 individuals with a body mass index (BMI > 35 kg/m) were enrolled.

Association between muscle mass assessed by an artificial intelligence-based ultrasound imaging system and quality of life in patients with cancer-related malnutrition.

Introduction: Emerging evidence suggests that diminished skeletal muscle mass is associated with lower health-related quality of life (HRQOL) in individuals with cancer. There are no studies that we know of in the literature that use ultrasound system to evaluate muscle mass and its relationship with HRQOL.

Objective: The aim of our study was to evaluate the relationship between HRQOL determined by the EuroQol-5D tool and muscle mass determined by an artificial intelligence-based ultrasound system at the rectus femoris (RF) level in outpatients with cancer.

Real-world study of 24 weeks to assess the effect of a partial meal replacement program on metabolic syndrome and its components in adult patients with obesity.

Background: meal replacement (MR) diets consist of replacing one or more meals. The objective was to evaluate the effect of a MR diet on weight reduction and metabolic syndrome (MS).

Methods: a real-world study was designed with a MR diet.

Impact of Hydroxy-Methyl-Butyrate Supplementation on Malnourished Patients Assessed Using AI-Enhanced Ultrasound Imaging.

Background: This study aimed to evaluate the effects of an oral nutritional supplement (ONS) enriched with hydroxy-methyl-butyrate (HMB) in subjects with disease-related malnutrition (DRM) and to monitor these effects with an ultrasound Imaging System, based on artificial intelligence, in a real-world study.

Methods: Fifty consecutive adult patients with DRM were enrolled. The malnutrition was diagnosed by Global Leadership Initiative on Malnutrition (GLIM) criteria.

Relationship between serum omentin-1 levels and nascent metabolic syndrome in Caucasian patients with obesity.

Background and aims: omentin-1 might present a potential role in metabolic syndrome (MS). The aim of our investigation was to evaluate the relationship between omentin-1 and nascent MS. Methods: we carried out a cross-sectional study in 606 obese subjects.

Evaluation of Muscle Mass and Malnutrition in Patients with Colorectal Cancer Using the Global Leadership Initiative on Malnutrition Criteria and Comparing Bioelectrical Impedance Analysis and Computed Tomography Measurements.

Objectives: The aim of this investigation was to evaluate the discrepancies between bioelectrical impedance analysis (BIA) and computed tomography (CT) in assessing skeletal muscle mass and identifying low muscle mass in patients with colorectal cancer.

Methods: This study recruited 137 patients with colorectal cancer from February 2028 to December 2023. CT scans were analyzed at the Lumbar 3 vertebral level to determine the area of skeletal muscle, which was then utilized to estimate whole-body skeletal muscle mass.

Validation of an Artificial Intelligence-Based Ultrasound Imaging System for Quantifying Muscle Architecture Parameters of the Rectus Femoris in Disease-Related Malnutrition (DRM).

(1) Background: The aim was to validate an AI-based system compared to the classic method of reading ultrasound images of the rectus femur (RF) muscle in a real cohort of patients with disease-related malnutrition. (2) Methods: One hundred adult patients with DRM aged 18 to 85 years were enrolled. The risk of DRM was assessed by the Global Leadership Initiative on Malnutrition (GLIM).

Impact of the rs822393 Variant on Adiponectin Levels and Metabolic Parameters after Weight Loss Secondary to a High-Fat Hypocaloric Diet with Mediterranean Pattern.

Introduction: The effects of the rs822393 variant of ADIPOQ gene on metabolic parameters such as insulin resistance and adiponectin levels following weight loss through dietary intervention are still uncertain. The aim of this study was to evaluate the role of rs822393 of ADIPOQ gene on adiponectin levels and metabolic parameters after weight loss with a high-fat hypocaloric diet with Mediterranean pattern during 12 weeks.

Methods: A population of 283 patients with obesity was allocated to a dietary intervention trial with a high-fat hypocaloric diet during 12 weeks.

Role of rs2282679 in 25-hydroxyvitamin D levels and insulin resistance after a sleeve gastrectomy.

Background & Aims: Some studies have reported links between 25-hydroxyvitamin D levels and the presence of obesity and some genetic variants. The aim of our design was to evaluate the effects of rs2282679 genetic variant of CG gene on 25-hydroxyvitamin D levels, weight loss and metabolic parameters after a robotic sleeve gastrectomy in premenopausal females with obesity.

Methods: 76 participants were enrolled.

Relationship between adiponectin and muscle mass in patients with metabolic syndrome and obesity.

Background: Adiponectin is one of the most important adipokines in human beings. Obesity and sarcopenia are associated with a low-level chronic inflammatory status, and adiponectin plays an anti-inflammatory role.

Aims: The objective of the current work was to study the association between muscle mass, determined via bioelectrical impedance (BIA), and circulating adiponectin levels among obese patients with metabolic syndrome who are older than 60 years of age.

Role of irisin and myostatin on sarcopenia in malnourished patients diagnosed with GLIM criteria.

Objectives: Sarcopenia is characterized by the loss of muscle mass. Skeletal muscle can produce and secrete different molecules called myokines. Irisin and myostatin are antagonistic myokines, and to our knowledge, no studies of both myokines have been conducted in patients with disease-related malnutrition (DRM).

Relationship between Mediterranean Diet and Phase Angle in a Sample of Patients with Obesity and Metabolic Syndrome.

Introduction: The potential influence of a Mediterranean diet (MD) on PhA values has been little researched. The aim of this study was to investigate the association between adherence of a MD and PhA on adult sample population with obesity and metabolic syndrome.

Methods: We conducted a cross-sectional study in 331 patients with obesity and metabolic syndrome.

Anthropometric, muscle and serum myokine levels effects of physical exercise with an online platform in female patients with obesity.

Introduction: Under physical exercise conditions, muscles can synthetise and release myokines and these molecules can exert paracrine and endocrine actions. Females with obesity have a sedentary lifestyle with alterations in myokine levels.

Objective: The aim of our study was to evaluate the effect of physical exercise on myokine levels, anthropometric parameters, clinical data, impedance parameters, and muscle ultrasound data in sedentary females with obesity.

Role of beta-2 adrenergic receptor polymorphism (rs1042714) on body weight and glucose metabolism response to a meal-replacement hypocaloric diet.

Objectives: The beta-2 adrenergic receptor (ADRB2) is involved in energy balance regulation. The objective of our study was to evaluate the role of the rs1042714 genetic variant of ADRB2 gene on weight loss, body composition, and metabolic changes secondary to partial meal replacement (pMR) hypocaloric diet in women with obesity.

Methods: We conducted an interventional study in 95 premenopausal women with body mass index ≥ 35 kg/m.

Relationship of circulating resistin levels with muscle mass determined by bioelectrical impedance in females with obesity.

Introduction: Serum resistin levels have been associated with obesity, visceral fat, and insulin resistance. Its relationship with muscle mass has been less evaluated.

Objectives: to evaluate the relationship between muscle mass determined by electrical bioimpedance and circulating resistin levels in obese women over 60 years of age.

Resistin/uric acid index as a marker of metabolic syndrome in females with obesity.

Background: The resistin/uric index has been considered a prognostic factor for identifying young people with obesity. Obesity and Metabolic Syndrome (MS) are an important health problem in females.

Aims: The objective of this work was to evaluate the relationship of resistin/acid uric index with Metabolic Syndrome on Caucasian females with obesity.

Role of resistin (rs7139228) gene polymorphism with metabolic response after a hypocaloric mediterranean diet.

Background: The SNP (rs7139228) of the RETN gene is a polymorphism that has been associated with metabolic disorder in subjects with obesity, and its effect on metabolic response after dietary intervention has not been evaluated.

Objective: Our objective was to analyse the effects of the polymorphism of the RETN gene rs7139228 on metabolic changes secondary to weight loss with a hypocaloric Mediterranean diet.

Design: 1000 obese Caucasian patients were evaluated.

Effects of a Short-Term Meal Replacement Hypocaloric Diet in Subjects with Obesity and High Fatty Liver Index.

Introduction: Dietary changes play a role in metabolic response of patients with metabolic-associated fatty liver disease, and there is little evidence on the use of partial meal replacement (pMR) diets in this pathology.

Aim: We decided to evaluate the modifications in transaminases levels after a pMR hypocaloric diet in subjects with obesity and elevated fatty liver index (FLI).

Material And Methods: A sample of 606 patients with obesity and FLI ≥ 60 were enrolled and treated during 3 months with a pMR diet.

A single FTO gene variant rs9939609 is associated with weight change and insulin resistance improvement in response to a robotic sleeve gastrectomy in individuals with severe obesity.

Background: Genetic mechanisms have been involved in the weight response secondary to bariatric surgery.

Objective: The aim of our study was to evaluate the effects of the rs9939609 genetic variant on weight loss and metabolic parameters after sleeve gastrectomy.

Setting: Tertiary hospital.