Publications by authors named "David M Carthwright"
J Endocrinol
November 2024
Article Synopsis
- Systemic excess of glucocorticoids, such as in Cushing's syndrome, leads to various metabolic issues, influenced by the enzyme 11β-HSD1.
- A study on mice revealed that high doses of corticosterone increased metabolic rates and carbohydrate use, especially in female wild type (WT) mice, but also caused fat accumulation.
- Notably, 11β-HSD1 knockout mice were protected from these metabolic changes, highlighting its role in the effects of glucocorticoid excess and hyperphagia.
