Outcomes Following First-Line Immune Checkpoint Inhibitors With or Without Chemotherapy Stratified by KRAS Mutational Status-A Real-World Analysis in Patients With Advanced NSCLC.

Introduction: Prior studies evaluating the efficacy of first line (1 L) immune checkpoint inhibitor (ICI) monotherapy or combined chemoimmunotherapy in advanced NSCLC found improved outcomes with chemoimmunotherapy independent of PD-L1 and KRAS mutation status. As such, combined chemoimmunotherapy was proposed as the preferred comparator arm for 1 L trials in KRAS mutated (KRAS mt) NSCLC. Herein, we report a multimodal, real world data (RWD) analysis for outcomes with 1 L therapy in patients with advanced NSCLC stratified by KRAS mutation status and PD-L1 levels.

The Impact of Assessment Schedules on Intimate Partner Violence Reporting in Young Adults.

Researchers have questioned the accuracy of participants' reports of the frequency of intimate partner violence (IPV). We used an experimental design to probe the adequacy of a 1-month recall period. Representatively sampled 18- to 19-year-old participants in romantic relationships ( = 435) were randomly assigned to self-report on the presence (/) and frequency of physical and psychological IPV perpetration and victimization on a monthly versus semimonthly basis.

International QEEG Certification Board Guideline Minimum Technical Requirements for Performing Clinical Quantitative Electroencephalography.

Quantitative electroencephalogram (QEEG) is a technology which has grown exponentially since the foundational publication by in Science in 1997, introducing the use of age-regressed metrics to quantify characteristics of the EEG signal, enhancing the clinical utility of EEG in neuropsychiatry. Essential to the validity and reliability of QEEG metrics is standardization of multi-channel EEG data acquisition which follows the standards set forth by the American Clinical Neurophysiology Society including accurate management of artifact and facilitation of proper visual inspection of EEG paroxysmal events both of which are expanded in this guideline. Additional requirements on the selection of EEG, quality reporting, and submission of the EEG to spectral, statistical, and topographic analysis are proposed.

A Proteomic Examination of Plasma Extracellular Vesicles Across Colorectal Cancer Stages Uncovers Biological Insights That Potentially Improve Prognosis.

Background: Recent advancements in understanding plasma extracellular vesicles (EVs) and their role in disease biology have provided additional unique insights into the study of Colorectal Cancer (CRC).

Methods: This study aimed to gain biological insights into disease progression from plasma-derived extracellular vesicle proteomic profiles of 80 patients (20 from each CRC stage I-IV) against 20 healthy age- and sex-matched controls using a high-resolution SWATH-MS proteomics with a reproducible centrifugation method to isolate plasma EVs.

Results: We applied the High-Stringency Human Proteome Project (HPP) guidelines for SWATH-MS analysis, which refined our initial EV protein identification from 1362 proteins (10,993 peptides) to a more reliable and confident subset of 853 proteins (6231 peptides).

Using Google Street View for virtual observations of neighborhoods and dwelling units: A feasibility study.

In face-to-face household surveys, field interviewers are sometimes asked to make notes of characteristics of the dwelling unit on the sampled address as well as its surroundings before making contact with a household member living at the sample address. Field interviewer observations of this kind are used to improve efficiency of field data collection and to be used as nonresponse adjustment. However, field interviewer observations can be expensive and the quality of observations needs to be improved.

Brief Report: Long-Term Follow-Up of Adjuvant Pembrolizumab After Locally Ablative Therapy for Oligometastatic NSCLC.

Introduction: Patients with oligometastatic NSCLC benefit from locally ablative therapies (LAT); the role of adjuvant systemic therapies, however, remains less clear. In a single-arm, phase II clinical trial, we found that patients with oligometastatic NSCLC treated with a year of pembrolizumab after LAT had superior progression-free survival (PFS) compared with a historical control cohort. Herein, we present long-term follow-up on PFS and overall survival (OS).

Transgenic, high-protein sorghums display promise in poultry diets in an initial comparison.

This study aimed to compare the inclusion of transgenic sorghums against commercially available sorghums on growth performance in broiler chickens. Isonitrogenous and isoenergetic diets were offered to a total 288 male Ross 308 broiler chickens from 14 to 35 d posthatch. Three dietary treatments were diets based on transgenic sorghums with a mean protein content of 154.

Rationale, Procedures, and Response Rates for a Pilot Study to Sample Cancer Survivors for NCI's Health Information National Trends Survey: HINTS-SEER 2021.

The National Cancer Institute's (NCI) Health Information National Trends Survey (HINTS) is a nationally representative survey of U.S. adults in which 12-17% of respondents report a cancer history.

Researching health and internal displacement: Introduction to the special series.

This special series on 'health and internal displacement' is concerned primarily with the health needs of internally displaced persons (IDPs) in conflict contexts. Curated by editors from the recently established Health and Internal Displacement Network (HIDN), the series brings together a selection of thirteen new research articles from among many submitted in response to an open call for papers by HIDN and the . The aims of this series are to increase engagement with the health needs of IDPs and to support research, policy and programming in this relatively neglected area.

Targeting KRAS-Mutated NSCLC: Novel TKIs and Beyond.

KRAS-mutated non-small cell lung cancer (NSCLC) is the most common genetically altered subtype of NSCLC, yet targeted therapies remain limited. Multiple studies have investigated combinations of MEK inhibitors with chemotherapy without success. Here we discuss these studies and novel approaches to targeting KRAS-mutated NSCLC.

Divergent dynamics: disasters and conflicts as 'drivers' of internal displacement?

Disasters and conflicts are both widely recognised as 'drivers' of internal displacement. Yet, despite a growing body of research and policy, there has been little consideration to date of how the different features of each 'context' shape the micro-level dynamics of internal displacement. Where and why are these dynamics similar across the two contexts and how do they differ? This paper draws on general concepts from the disaster field to develop a comparative analytical model of internal displacement dynamics in the disaster and conflict contexts.

Analysis of health overseas development aid for internally displaced persons in low- and middle-income countries.

Background: There are an estimated 55 million internally displaced persons (IDPs) globally. IDPs commonly have worse health outcomes than host populations and other forcibly displaced populations such as refugees. Official development assistance (ODA) is a major source of the global financial response for health in low- and middle-income countries (LMICs), including for populations affected by armed conflict and forced displacement.

Three-dimensional compaction of soft granular packings.

This paper analyzes the compaction behavior of assemblies composed of soft (elastic) spherical particles beyond the jammed state, using three-dimensional non-smooth contact dynamic simulations. The assemblies of particles are characterized using the evolution of the packing fraction, the coordination number, and the von Misses stress distribution within the particles as the confining stress increases. The packing fraction increases and tends toward a maximum value close to 1, and the mean coordination number increases as a square root of the packing fraction.

Understanding the health needs of internally displaced persons: A scoping review.

We seek to strengthen understanding of the health needs of internally displaced persons (IDPs) in contexts of conflict or violence. Based upon a scoping review, our paper identified limited evidence on IDP health, but nevertheless indicates that IDPs tend to experience worse health outcomes than other conflict-affected populations across a range of health issues; and this is due to the particularly vulnerable situation of IDPs relative to these other populations, including reduced access to health services. Further research is required to better understand these needs and the interventions that can most effectively address these needs.

Implications of excreta uric acid concentrations in broilers offered reduced-crude protein diets and dietary glycine requirements for uric acid synthesis.

In a previous experiment, male Ross 308 broiler chickens were offered dietary treatments with 3 levels of crude protein (222, 193, 165 g/kg) and 3 feed grains (ground maize, ground wheat, whole wheat) from 7 to 35 d post-hatch. Maize-based diets supported superior growth performance in comparison to wheat-based diets. Uric acid concentrations in excreta were retrospectively determined and related to total nitrogen (N) excreta concentrations.

Micromechanical description of the compaction of soft pentagon assemblies.

We analyze the isotropic compaction of assemblies composed of soft pentagons interacting through classical Coulomb friction via numerical simulations. The effect of the initial particle shape is discussed by comparing packings of pentagons with packings of soft circular particles. We characterize the evolution of the packing fraction, the elastic modulus, and the microstructure (particle rearrangement, connectivity, contact force, and particle stress distributions) as a function of the applied stresses.

Compaction of mixtures of rigid and highly deformable particles: A micromechanical model.

We analyze the isotropic compaction of mixtures composed of rigid and deformable incompressible particles by the nonsmooth contact dynamics approach. The deformable bodies are simulated using a hyperelastic neo-Hookean constitutive law by means of classical finite elements. We characterize the evolution of the packing fraction, the elastic modulus, and the connectivity as a function of the applied stresses when varying the interparticle coefficient of friction.

Microstructural analysis of sheared polydisperse polyhedral grains.

This article presents an analysis of the shear strength of numerical samples composed of polyhedra presenting a grain size dispersion. Previous numerical studies using, for instance, disks, polygons, and spheres, have consistently shown that microstructural properties linked to the fabric and force transmission allow granular media to exhibit a constant shear resistance although packing fraction can dramatically change as a broader grain-size distribution is considered. To have a complete picture of such behavior, we developed a set of numerical experiments in the frame of the discrete element method to test the shear strength of polydisperse samples composed of polyhedral grains.

Compaction Model for Highly Deformable Particle Assemblies.

The compaction behavior of deformable grain assemblies beyond jamming remains bewildering, and existing models that seek to find the relationship between the confining pressure P and solid fraction ϕ end up settling for empirical strategies or fitting parameters. Using a coupled discrete-finite element method, we analyze assemblies of highly deformable frictional grains under compression. We show that the solid fraction evolves nonlinearly from the jamming point and asymptotically tends to unity.

Proteomic investigations into resistance in colorectal cancer.

: Despite advances in screening and treatment options, colorectal cancer (CRC) remains one of the most prevalent and lethal cancer subtypes. Resistance to cytotoxic or targeted therapy has remained a constant challenge to the treatment and long-term management of patients, attracting intense worldwide investigation since the 1950s. Through extensive investigations into the proteomic mechanisms and functions that convey resistance to therapy/s, researchers have become able to implicate alterations in several signaling pathways that provide and sustain resistance to treatment.

Asking Survey Questions About Criminal Justice Involvement.

Criminal justice involvement is a multifaceted construct encompassing various forms of contact with the criminal justice system. It is a sensitive topic to ask about in surveys and also a sensitive topic for respondents to answer. This article provides guidance for writing survey questions on criminal justice involvement, starting with a review of potential causes for reporting error and nonresponse error associated with survey questions on criminal justice involvement.