Publications by authors named "Dario Guido Di Febbraro"
Article Synopsis
- Circulating Tumor Cells (CTCs) are rare cancer cells that can lead to metastasis; a new gel (CLG) containing CXCL12 was created to attract and study these cells, particularly those expressing CXCR4 that facilitate invasion.
- Different cancer cell lines (colon, renal, lung, and ovarian) were tested on the gel, revealing that the CXCL12-loaded gel significantly enhanced the ability of CTCs to infiltrate compared to an empty gel.
- In a clinical trial, CTCs were successfully isolated from patients with ovarian and lung cancers using the CLG, showing promising results in identifying metastatic cells and understanding their behavior.
