Publications by authors named "Daniela Pastore"
Asthma is a highly heterogeneous respiratory disease that, in its severe forms, is characterized by persistent symptoms, frequent exacerbations, and a significant impact on patients' quality of life. Despite high-dose inhaled corticosteroids and long-acting bronchodilators, a subset of patients remains uncontrolled, necessitating advanced therapeutic strategies. The advent of biologic therapies has revolutionized the management of severe asthma, offering targeted interventions based on the underlying inflammatory endotypes, primarily T2-high and T2-low.
View Article and Find Full Text PDFIntroduction: Severe asthma is a chronic airway disease characterized by many pathomechanisms known as endotypes. Biological therapies targeting severe asthma endotypes have significantly improved the treatment of this disease, thus remarkably bettering patient quality of life.
Areas Covered: This review aims to describe current biological therapies for severe asthma, highlighting emerging ones.
Article Synopsis
- Severe asthma can be understood through different types called phenotypes, which are linked to complex biological causes known as endotypes.
- * Researchers have found that new treatments using antibodies can help people with different types of severe asthma, especially those related to allergies and certain immune responses.
- * There is hope for better treatments in the future for people with a type of severe asthma that currently doesn't have good treatment options, which could help improve their lives.