Locomotor activity alterations in zebrafish following cisplatin exposure: An assessment of neurobehavioral toxicity.

Cisplatin is a widely used chemotherapeutic agent for treating solid tumors. However, its extensive clinical application raises environmental concerns, as it has been detected in wastewater effluents at concentrations as high as 150 μg/L. Even though recent studies indicate that even sub-lethal concentrations of cisplatin may induce neurobehavioral toxicity in aquatic organisms, the precise mechanism underlying cisplatin-induced behavioral disturbances remains unclear.

Assessing cisplatin-induced acute toxicity in zebrafish (Danio rerio): a multi-organ perspective at realistic concentrations.

Cisplatin, a widely used platinum-based chemotherapeutic agent, has been detected in hospital effluents and wastewater treatment plant discharges, raising concerns about its potential ecological impact, particularly on aquatic organisms. Despite its significant presence in environmental matrices, limited studies have investigated the effects of cisplatin at concentrations within the lower range of those reported in wastewater treatment plant effluents (< 150 μg/L) on fish health. This study aimed to assess the impact of cisplatin (2, 5, 10 μg/L) on zebrafish (Danio rerio) by evaluating oxidative stress responses and gene expression alterations in critical organs, including the liver, brain, gut, and gills.

Overview and expression of GLUT in gestational diabetes mellitus: A literature review.

Introduction: Gestational diabetes mellitus (GDM) is an endocrine-metabolic disorder that develops during pregnancy. Glucose transporters (GLUTs), which facilitate the transport of glucose across the plasma membrane (facilitated diffusion) play a key role in the progression of this disease.

Objective: This study aimed to analyze the general characteristics and expression of GLUTs in GDM.