Dual mode of action herbicide rimisoxafen targets both phytoene desaturase and solanesyl diphosphate synthase.

Background: The need for new, efficacious, and safe crop protection chemistries to control evolving pest populations is ever-present to combat resistance derived from current crop protection offerings. Rimisoxafen is a novel pyrimidinyloxy benzene with herbicidal activity. Determination of mode of action (MoA) is key to de-risking newly introduced crop protection chemistries with regards to toxicology and the potential for field resistance.

A synchronized event-cue feedback loop integrating a 3D printed wearable flexible sensor-tactor platform.

Wearable devices designed for the somatosensory system aim to provide event-cue feedback electronics and therapeutic stimulation to the peripheral nervous system. This prompts a neurological response that is relayed back to the central nervous system. Unlike virtual reality tools, these devices precisely target peripheral mechanoreceptors by administering specific stimuli.

Diagnostic challenges with transesophageal echocardiography for intraoperative iatrogenic aortic dissection: Role of epiaortic ultrasound.

Iatrogenic aortic dissection is a rare and serious complication of cardiac surgery with an incidence between 0.12' and 0.16'.

Pyrrole-2 carboxamides - A novel class of insect ryanodine receptor activators.

The ryanodine receptor (RyR) is an intracellular calcium channel critical to the regulation of insect muscle contraction and the target site of diamide insecticides such as chlorantraniliprole, cyantraniliprole and flubendiamide. To-date, diamides are the only known class of synthetic molecules with high potency against insect RyRs. Target-based screening of an informer library led to discovery of a novel class of RyR activators, pyrrole-2-carboxamides.

Timing of Gastrointestinal Bleeding After Implantation of Left Ventricular Assist Devices Associates With Anatomic Location, Presentation, and Management.

Background & Aims: Continuous-flow left ventricular assist devices (LVADs) for advanced heart failure have been associated with gastrointestinal bleeding (GIB). We examined the association between time of GIB after LVAD implantation and bleeding location (determined by endoscopy), etiology, and patient outcomes.

Methods: We performed a retrospective study of consecutive patients who underwent implantation of continuous-flow LVADs from 2008 through 2015.

A Patient-Controlled Analgesia Adaptor to Mitigate Postsurgical Pain for Combat Casualties With Multiple Limb Amputation: A Case Series.

The use of explosive armaments during Operation Iraqi Freedom, Operation Enduring Freedom, and Operation New Dawn has resulted in a significant number of injured U.S. service members.

Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs.

Afoxolaner is an isoxazoline compound characterized by a good safety profile and extended effectiveness against fleas and ticks on dogs following a single oral administration. In vitro membrane feeding assay data and in vivo pharmacokinetic studies in dogs established an afoxolaner blood concentration of 0.1-0.

Identification of a critical region in the Drosophila ryanodine receptor that confers sensitivity to diamide insecticides.

Anthranilic diamides, which include the new commercial insecticide, chlorantraniliprole, are an exciting new class of chemistry that target insect ryanodine receptors. These receptors regulate release of stored intracellular calcium and play a critical role in muscle contraction. As with insects, nematodes express ryanodine receptors and are sensitive to the plant alkaloid, ryanodine.

Preoperative risk stratification reduces the incidence of perioperative complications after total knee arthroplasty.

The purpose of this study was to validate a screening and management protocol to identify and reduce risk of renal, pulmonary, and delirium complications. A cohort study comparing incidence of perioperative complications on a consecutive series of patients undergoing total knee arthroplasty with a historical control group was conducted. The study cohort was evaluated prospectively to identify and reduce noncardiac medical complications.