Publications by authors named "Danai Fimereli"
Article Synopsis
- The ZEPHIR clinical trial aimed to assess how [89Zr]trastuzumab-PET/CT and [18F]FDG-PET/CT can predict outcomes in patients with advanced HER2-positive breast cancer receiving trastuzumab emtansine (T-DM1).
- Researchers integrated imaging data from PET/CT scans and gene expression data from biopsy samples to understand the relationship between drug uptake and biological processes in the tumors.
- The study revealed that low uptake of [89Zr]trastuzumab was linked to ECM-related gene pathways, while high uptake correlated with immune responses, highlighting the importance of ECM in affecting drug uptake and treatment response in these patients.
Prognostic Value of Circulating Cytokines in Chemorefractory Colorectal Cancer.
Cancers (Basel)
December 2023
Circulating cytokines could be optimal biomarkers for prognostication and management decisions in colorectal cancer (CRC). Chemorefractory CRC patients with available plasma samples were included in this study. In the discovery cohort ( = 85), 182 circulating cytokines were tested with a semi-quantitative multiplex assay, and prognostic cytokines were analyzed in the validation cohort ( = 111) by ELISA.
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- Late recurrence of invasive lobular carcinoma (ILC) presents challenges in treatment, with limited understanding of its metastatic molecular landscape.
- Researchers analyzed 38 ILC patients by sequencing DNA from both primary and metastatic tissues to uncover patterns in cancer evolution and metastatic spread.
- Findings revealed varied seeding patterns and timelines for metastasis, with some patients experiencing a dormant phase and notable changes in cancer-driving genes, suggesting the need for improved ILC treatment strategies.
Background: We aimed to determine the distribution of intrinsic subtypes within HER2-low breast cancer (BC), and to describe the prognostic impact of HER2-low status on survival outcomes.
Methods: This is a retrospective, observational study of primary BC extracted from The Cancer Genome Atlas dataset. We described the distribution of PAM50 intrinsic subtypes within HER2-low BC subtype according to hormonal receptor status (positive (HR+) and negative (HR-)).
Background: In breast cancer (BC), axillary lymph node (ALN) involvement is one of the strongest adverse prognostic factors. However, it is unclear whether loco-regional lymph node deposits are effectively the root of secondary metastases or only an indicator of competence of the primary tumour to spread to distant organs.
Methods: Here, we investigated the evolutionary trajectories of primary tumour, ALN and distant metastasis samples from 16 estrogen-receptor (ER)-positive lymph node-positive BC patients.
Genomic hotspots but few recurrent fusion genes in breast cancer.
Genes Chromosomes Cancer
July 2018
The advent of next generation sequencing technologies has boosted the interest in exploring the role of fusion genes in the development and progression of solid tumors. In breast cancer, most of the detected gene fusions seem to be "passenger" events while the presence of recurrent and driver fusions is still under study. We performed RNA sequencing in 55 well-characterized breast cancer samples and 10 adjacent normal breast tissues, complemented by an analysis of SNP array data.
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- miRNA expression profiles are essential in understanding non-medullary thyroid carcinomas, which are common endocrine cancers, and could help in creating new diagnostic tests and therapies.
- Variability in research strategies has led to discrepancies in study results, and the nuanced role of miRNAs is often overlooked due to rigid concepts.
- Recent advancements, including next-generation sequencing, have improved insight into miRNA behavior in papillary thyroid carcinoma, prompting a detailed review of existing literature and suggestions for future research directions that could apply to other cancer types as well.
Background: Studies evaluating the presence of viral sequences in breast cancer (BC), including various strains of human papillomavirus and human herpes virus, have yielded conflicting results. Most were based on RT-PCR and in situ hybridization.
Methods: In this report we searched for expressed viral sequences in 58 BC transcriptomes using five distinct in silico methods.
The contribution of intratumor heterogeneity to thyroid metastatic cancers is still unknown. The clonal relationships between the primary thyroid tumors and lymph nodes (LN) or distant metastases are also poorly understood. The objective of this study was to determine the phylogenetic relationships between matched primary thyroid tumors and metastases.
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Nucleic Acids Res
April 2013
High-throughput sequencing is becoming a popular research tool but carries with it considerable costs in terms of computation time, data storage and bandwidth. Meanwhile, some research applications focusing on individual genes or pathways do not necessitate processing of a full sequencing dataset. Thus, it is desirable to partition a large dataset into smaller, manageable, but relevant pieces.
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