Publications by authors named "Danae S Sharp"
Proc Natl Acad Sci U S A
November 2023
Article Synopsis
- Robust high-throughput assays are essential in drug discovery, and this study introduces Invasion-Block, an automated platform for analyzing how cancer cells invade through tissue.
- Using this platform, researchers screened nearly 4000 FDA-approved drugs and another 210 kinase inhibitors, discovering that certain inhibitors notably decreased the invasive behavior of melanoma cells.
- The study highlights that targeting the ATM kinase could be a promising strategy for developing treatments to prevent melanoma metastasis in patients.
