Publications by authors named "Dagmar Rudzki"
Background: Erythropoietin (EPO) plays a crucial role in the early adaption to high altitude and is possibly involved in neuroprotection. Neurofilament light chain (NfL) is an established marker of neuroaxonal damage.
Objective: To investigate whether EPO dynamics in simulated high altitude are linked to neuroaxonal damage as measured by NfL.
Article Synopsis
- Researchers studied the inflammatory response in 173 patients with acute ischaemic stroke by measuring 65 cytokines and chemokines in their plasma, finding varied profiles based on inflammatory levels.
- Stroke patients showed higher levels of compounds like HGF and SDF-1α and lower IL-4 compared to those with spontaneous cervical artery dissection, suggesting different inflammatory responses.
- The analysis revealed that stroke from large artery atherosclerosis, cardioembolism, and small vessel occlusion leads to a greater inflammatory response than spontaneous cervical artery dissection, with stable cytokine levels over time.
Article Synopsis
- Recent studies suggest that myelin oligodendrocyte glycoprotein antibody-associated disease could be a rare complication linked to either SARS-CoV-2 infection or vaccination.
- The research aims to determine if there's an immune response overlap between SARS-CoV-2 proteins and myelin oligodendrocyte glycoprotein, which could explain the condition's occurrence.
- Serum samples from various groups with different histories of SARS-CoV-2 infection and neurological symptoms were analyzed to assess antibody responses against both myelin oligodendrocyte glycoprotein and SARS-CoV-2, among other common coronaviruses.
Introduction: The understanding of the pathophysiology of multiple sclerosis (MS) has evolved alongside the characterization of cytokines and chemokines in cerebrospinal fluid (CSF) and serum. However, the complex interplay of pro- and anti-inflammatory cytokines and chemokines in different body fluids in people with MS (pwMS) and their association with disease progression is still not well understood and needs further investigation. Therefore, the aim of this study was to profile a total of 65 cytokines, chemokines, and related molecules in paired serum and CSF samples of pwMS at disease onset.
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- The study focuses on rare demyelinating diseases like MOGAD and AQP4+ NMOSD, which can lead to significant disability and exhibit distinct inflammatory profiles compared to multiple sclerosis (MS).
- Researchers analyzed 65 serum molecules in patients from each disease group, finding that MOGAD and AQP4+ NMOSD showed notable increases in certain analytes compared to MS, with some differences in cytokine patterns between age groups.
- The analysis identified three distinct clusters of patients based on cytokine profiles, suggesting potential biomarkers that could aid in the diagnosis and treatment of these autoimmune disorders.
Background: Natalizumab (NTZ) is an established treatment for highly active, relapsing-remitting multiple sclerosis. In the context of rare progressive multifocal leukoencephalopathy and extended interval dosing as a treatment option, biomarkers for treatment monitoring are required. Natalizumab serum concentration (NTZ SC) and soluble vascular cell adhesion molecule 1 (sVCAM-1) concentration were shown to change on treatment with NTZ.
View Article and Find Full Text PDF12-month SARS-CoV-2 antibody persistency in a Tyrolean COVID-19 cohort.
Wien Klin Wochenschr
December 2021
Article Synopsis
- - The study tracked 29 COVID-19 patients over 12 months to analyze their antibody responses post-infection, focusing on different types of antibodies targeting various parts of the virus.
- - Results showed that the levels of antibodies targeting the receptor binding domain (RBD) remained stable, while others, like the S1 subunit, significantly decreased over time; neutralizing antibodies were mostly found against the wild type but less effectively against variants.
- - Vaccinated participants exhibited a notable increase in antibodies against both the S1 subunit and RBD, along with higher levels of neutralizing antibodies, indicating that vaccination boosts the immune response even after prior COVID-19 infection.
Objectives: To evaluate skin biopsies of patients with early- and late onset restless legs syndrome (RLS) for concomitant small fiber neuropathy (SFN) and to determine cutaneous sympathetic innervation and microvascularization in comparison to healthy individuals.
Methods: Density of intraepidermal nerve fibers (IENFD), adrenergic nerve fibers and dermal capillaries was analyzed by immunofluorescence for PGP9.5, tyrosine hydroxylase and endothelial markers CD31 and CD105 in skin biopsies of 11 individuals with RLS and 8 age- and sex-matched controls.
6-month SARS-CoV-2 antibody persistency in a Tyrolian COVID-19 cohort.
Wien Klin Wochenschr
April 2021
Background: As coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 evolved only recently, the persistency of the anti-viral antibody response remains to be determined.
Methods: We prospectively followed 29 coronavirus disease 2019 cases, mean age 44 ± 13.2 years.
Friedreich's Ataxia (FRDA) is caused by a homozygous intronic GAA expansion in the FXN gene. FRDA affects primarily the peripheral nervous system (PNS) with cumulative evidence from postmortem studies and in vitro models suggesting a developmental component of its pathology. In the present study, we aimed at gaining further insight in the PNS involvement in FRDA by investigating small nerve fibers in vivo.
View Article and Find Full Text PDFUtility of Two-Dimensional Difference Gel Electrophoresis in Diagnosis of Multiple Sclerosis.
Diagnostics (Basel)
July 2018
Two-dimensional difference gel electrophoresis (2D-DIGE) has been used for identification of possible biomarkers in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. However, in different studies inconsistent results have been obtained. We wanted to analyze the diagnostic value of 2D-DIGE in early MS patients by comparing protein patterns between single and pooled samples of MS patients and controls.
View Article and Find Full Text PDFCytokine profiles show heterogeneity of interferon-β response in multiple sclerosis patients.
Neurol Neuroimmunol Neuroinflamm
April 2016
Objective: To evaluate serum cytokine profiles for their utility to determine the heterogeneous responses to interferon (IFN)-β treatment in patients with multiple sclerosis (MS).
Methods: Patients with relapsing-remitting MS (RRMS) or clinically isolated syndrome receiving de novo IFN-β treatment were included in this prospective, observational study. Number of relapses and changes in disability were assessed 2 years prior to and 2 years after initiation of treatment.
Vascular cell adhesion molecule-1 a ligand for leukocyte very late activating antigen-4 is a key player in leukocyte extravasation in MS lesions. Natalizumab a monoclonal antibody against VLA-4 blocks this interaction. VCAM-1 and its soluble form are up-regulated during endothelial activation in MS.
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