Local recurrence rates of horizontal margin-positive en bloc endoscopic submucosal dissection of colorectal neoplasia: a meta-analysis.

Background And Aims: Endoscopic submucosal dissection (ESD) enables en bloc resection of large colorectal neoplasms, but the recurrence risk with positive or indeterminate horizontal margins (HM1/x) remains debated. This meta-analysis evaluated the local recurrence rate after en bloc ESD with HM1/x margins.

Methods: A systematic search of PubMed, EMBASE, Web of Science, and Cochrane Library through June 2024 identified studies reporting local recurrence after colorectal en bloc ESD with HM1/x margins.

T1 colorectal cancer patients' perspective on information provision and therapeutic decision-making after local resection.

Background: Decision-making after local resection of T1 colorectal cancer (T1CRC) is often complex and calls for optimal information provision as well as active patient involvement.

Objective: The aim was to evaluate the perceptions of patients with T1CRC on information provision and therapeutic decision-making.

Methods: This multicenter cross-sectional study included patients who underwent endoscopic or local surgical resection as initial treatment.

Management after non-curative endoscopic resection of T1 rectal cancer.

Since the introduction of population-based screening, increasing numbers of T1 rectal cancers are detected and removed by local endoscopic resection. Patients can be cured with endoscopic resection alone, but there is a possibility of residual tumor cells remaining after the initial resection. These can be located intraluminally at the resection site or extraluminally in the form of (lymph node) metastases.