RACK1A positively regulates opening of the apical hook in via suppression of its auxin response gradient.

Apical hook development is an ideal model for studying differential growth in plants and is controlled by complex phytohormonal crosstalk, with auxin being the major player. Here, we identified a bioactive small molecule that decelerates apical hook opening in . Our genetic studies suggest that this molecule enhances or maintains the auxin maximum found in the inner hook side and requires certain auxin signaling components to modulate apical hook opening.

Phosphatidylethanol and ethyl glucuronide to categorize alcohol consumption in alcohol-related cirrhosis.

Background & Aims: Phosphatidylethanol (PEth) is an alcohol-use biomarker that could bridge the detection windows of urinary ethyl glucuronide (uEtG) and scalp hair ethyl glucuronide (hEtG), but has been rarely validated in patients with liver disease. Reported detection windows of these biomarkers also vary significantly, and available studies have focused solely on any alcohol use. Yet, categorizing patients with liver disease based on their level of alcohol use would be highly informative.

Applications of schema therapy in young people: a systematic review.

Adolescents and young adults are increasingly susceptible to developing mental health conditions, but many young people do not respond well to the current evidence-based treatments. Schema therapy has been effective in adults with mental health conditions, and research suggests it holds promise in adolescents with chronic or treatment-resistant mental health conditions. Our systematic review searched for articles that applied schema therapy in people aged between 12 and 30.

Multiplex IgE peanut panels: a critical appraisal of assay designs and the good, the bad, and the ugly features of the applied allergen components.

Background: Multiplex allergy assays are currently well-established in allergy diagnostics. However, the different assays in terms of designs and performance are also claimed to be heterogeneous as no agreed standards and requirements are available.

Objective: We aimed to compare the analytical assay designs of the ISAC, ALEX, and EUROLINE peanut (Ara h) panels and the features of the applied isoallergens and variants to create more awareness of the heterogeneity of multiplex allergy assays.

Exploring the physiotherapy and exercise needs and preferences of nursing home residents with dementia: A qualitative study.

Background: Exercise is widely employed to prevent functional decline in individuals with Alzheimer's disease and other forms of dementia. Exercise interventions are often supervised by physiotherapists, particularly in Western countries. However, adherence to exercise-based interventions remains suboptimal, particularly among nursing home residents.