Retrospective study on the effectiveness of punch drilling combined with superficial X-ray radiotherapy and intralesional drug injection for keloid treatment.

Background: Keloids, pathological scars with complex etiology including genetic predisposition and trauma, remain a therapeutic challenge due to high recurrence rates. This study intends to conduct a retrospective study on the patients who received punch drilling therapy for keloid in our hospital to provide a new method and objective basis for the treatment of keloid.

Methods: A retrospective analysis of 13 patients (20 keloids) treated at Dermatology Hospital of Southern Medical University was conducted.

Plasma metabolites mediate the effects of circulating immune cell phenotypes on prostate cancer: A 2-step Mendelian randomization study.

Prior research suggested the potential correlation between circulating immune cell phenotypes and prostate cancer (PCa). However, it remains unclear whether the correlation can be mediated by plasma metabolites. We performed a bidirectional 2-sample, 2-step Mendelian randomization (MR) study mainly utilizing the inverse variance weighted method to examine the causal role of circulating immunophenotypes on PCa and explore the mediation effect of plasma metabolites in the pathway from immunophenotypes to PCa.

Biopreservation technology of sourdough co-fermented with Fructilactobacillus sanfranciscensis and Propionibacterium freudenreichii: Effects and mechanisms for enhancing bread quality and extending shelf life.

This study presents a biopreservation method using sourdough co-fermented with Fructilactobacillus sanfranciscensis and Propionibacterium freudenreichii, optimizing conditions to 220 hydration and 24 h fermentation. The composite sourdough bread quality was evaluated through physicochemical, storage, sensory, and microbial tests, with mechanisms analyzed based on microstructure, rheology, and dough structure. Results showed that: first, the composite sourdough enhanced bread physicochemical properties, increasing volume, height-to-diameter ratio, elasticity, and resilience, while reducing baking loss, hardness, chewiness, and adhesiveness.

Interaction between diabetes and osteoporosis: imbalance between inflammation and bone remodeling.

Diabetes and osteoporosis are common chronic diseases worldwide, and there is a complex pathological relationship between the two. Due to hyperglycemia, insulin resistance, and accumulation of advanced glycation end products (AGEs), diabetic patients often show a higher risk of fractures. At the same time, chronic low-grade inflammation and oxidative stress caused by diabetes also play an important role in the occurrence of osteoporosis, disrupting the balance of bone remodeling.

SAMCell: Generalized label-free biological cell segmentation with segment anything.

Background: When analyzing cells in culture, assessing cell morphology (shape), confluency (density), and growth patterns are necessary for understanding cell health. These parameters are generally obtained by a skilled biologist inspecting light microscope images, but this can become very laborious for high-throughput applications. One way to speed up this process is by automating cell segmentation.